Indications
Empadi 25 Tablet is used for:
Type 2 diabetes mellitus
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: Initially, 10 mg once daily in the morning, may be increased to 25 mg once daily, if necessary for additional glycemic control.
Child Dose
Renal Dose
CrCl (mL/min)
<45 Contraindicated.
<60 Max: 10 mg daily.
Administration
May be taken with or without food.
Contra Indications
As treatment for type 1 DM or diabetic ketoacidosis. Renal impairment (CrCl <45 mL/min), ESRD, or patients on haemodialysis. Lactation.
Precautions
Hypotension: Before initiating Empagliflozin, volume status should be assessed and correction on hypovolemia should be made in the elderly, in patients with renal impairment, in patients with low systolic blood pressure and in patients on diuretics since Empagliflozin causes intravascular volume contraction.
Impairment in Renal Function: Renal function should be evaluated prior to initiating Empagliflozin and periodically thereafter since Empagliflozin increases serum creatinine and decreases eGFR.
Hypoglycemia: In patients taking insulin or an insulin secretagogue with Empagliflozin, a lower dose of insulin or the insulin secretagogue is considered to reduce the risk of hypoglycemia.
Genital mycotic infections: Monitoring and treatment should be done if indicated. Urinary Tract Infections: Monitoring and treatment should be done as appropriate.
Increased LDL-C: Monitoring and treatment should be initiated if required.
Lactation: Discontinue Empagliflozin or discontinue lactation.
Pregnancy-Lactation
Pregnancy
Based on animal data showing adverse renal effects, use not recommended during the second and third trimesters of pregnancy
Limited data available in pregnant women are insufficient to determine a drug-associated risk for major birth defects and miscarriage
There are risks to the mother and fetus associated with poorly controlled diabetes in pregnancy
Clinical considerations
Poorly controlled diabetes in pregnancy increases maternal risk for diabetic ketoacidosis, pre-eclampsia, spontaneous abortions, preterm delivery, stillbirth, and delivery complications; poorly controlled diabetes increases fetal risk for major birth defects, still birth, and macrosomia related morbidity
Lactation
There is no information regarding presence in human milk, the effects on breastfed infant or on milk production
Empagliflozin is present in the milk of lactating rats
Because of potential for serious adverse reactions in a breastfed infant, advise women that it is not recommended while breastfeeding
Interactions
Additive hypoglycaemic effect if concomitantly used w/ insulin and insulin secretagogues (e.g. sulfonylureas). Increased risk of dehydration and hypotension when used w/ diuretics (e.g. thiazides, loop diuretics).
Side Effects
Side effects of Empagliflozin :
1-10%
Urinary tract infection (7.6-9.3%)
Female genital mycotic infections (5.4-6.4%)
Upper respiratory tract infection (3.1-4%)
Increased urination (3.2-3.4%)
Dyslipidemia (2.3-2.4%)
Male genital mycotic infections (1.6-3.1%)
Nausea (1.1-2.3%)
Polydipsia (1.5-1.7%)
Mode of Action
Empagliflozin is a reversible inhibitor of sodium-glucose co-transporter 2 (SGLT2), the main site of filtered glucose re-absorption in the renal proximal convoluted tubules. This reduces re-absorption of filtered glucose and lowers renal threshold for glucose, resulting in increased urinary glucose excretion, thereby reducing blood glucose concentration.
Note
Empadi 25 25 mg Tablet generic name is Empagliflozin. Empadi 25 25 mg Tablet is manufactured by Pacific Pharmaceuticals Ltd.Empadi 25 is availble in all over Bangladesh.
Mes BD drug index information on Empadi 25 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.