Eluxan 75 Tablet
Eluxadoline
75mg
Ziska Pharmaceuticals Ltd.
| Pack size | 10's Pack |
|---|---|
| Unite Price | 125.00 BDT |
Indications
Eluxan 75 Tablet is used for:
Indicated for diarrhea-predominant, irritable bowel syndrome (IBS-D), in adult men and women
Adult Dose
Irritable Bowel Syndrome
Indicated for diarrhea-predominant irritable bowel syndrome (IBS-D) in adult men and women
100 mg PO BID with food
Discontinue in patients who develop severe constipation lasting >4 days
Hepatic impairment
Mild-to-moderate (Child-Pugh A or B): Decrease dose to 75 mg PO BID; monitor for impaired mental or physical abilities needed to perform potentially hazardous activities
Severe (Child-Pugh C): Contraindicated
Child Dose
Renal Dose
Administration
May be taken with food.
Contra Indications
Documented hypersensitivity to drug or components of the formulation
Patients who do not have a gallbladder
Known or suspected gallbladder obstruction, biliary duct obstruction or sphincter of Oddi disease or dysfunction; increased risk for sphincter of Oddi spasm
Alcoholism, alcohol abuse, alcohol addiction, or in patients who drink >3 alcoholic beverages/day; increased risk of pancreatitis
History of pancreatitis, pancreatic duct obstruction, or structural diseases of the pancreas; increased risk of acute pancreatitis
Severe hepatic impairment (Child-Pugh C); risk of significantly increased eluxadoline plasma concentrations
Precautions
Eluxadoline is a mu opioid receptor agonist; because of this mechanism of action, the potential for increased risk of sphincter of Oddi spasm exists, resulting in pancreatitis or hepatic enzyme elevation associated with acute abdominal pain
In patients with a gallbladder, evaluate a patient’s alcohol intake prior to starting therapy; instruct patients to avoid chronic or acute excessive alcohol use while in therapy; monitor for new or worsening abdominal pain that may radiate to back or shoulder, with or without nausea and vomiting; instruct patients to immediately stop therapy and seek medical attention if they experience symptoms suggestive of pancreatitis such as acute abdominal or epigastric pain radiating to back or shoulder associated with elevations of pancreatic enzymes with or without nausea and vomiting
Lactation
Unknown if distributed in human breast milk
Secreted in rat milk
Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition
Pregnancy-Lactation
Pregnancy
No studies in pregnant women
Animal reproduction studies
Oral and SC administration of eluxadoline to rats and rabbits during organogenesis at doses approximately 51 and 115 times the human exposure after a single oral dose of 100 mg, respectively, demonstrated no teratogenic effects. In a prenatal and postnatal development study in rats
No adverse effects were observed in offspring with oral administration of eluxadoline at doses approximately 10 times the human exposure
Lactation
Unknown if distributed in human breast milk
Secreted in rat milk
Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition
Interactions
Side Effects
Side effects of Eluxadoline :
1-10%
Constipation (7-8%)
Nausea (7-8%)
Abdominal pain (6-7%)
URT infection (3-5%)
Vomiting (4%)
Nasopharyngitis (3-4%)
Abdominal distention (3%)
Bronchitis (3%)
Dizziness (3%)
Flatulence (3%)
Rash (3%)
Increased ALT (2-3%)
Fatigue (2-3%)
Viral gastroenteritis (1-3%)
<2%
Gastrointestinal: GERD
General disorders: Feeling drunk
Investigations: Increased AST
Nervous system: Sedation, somnolence
Psychiatric disorders: Euphoric mood
Respiratory: Asthma, bronchospasm, respiratory failure, wheezing
<1%
Severe constipation
Mode of Action
Mu opioid receptor agonist; it also is a delta opioid receptor antagonist and a kappa opioid receptor agonist
The multiple opioid activity is designed to treat the symptoms of IBS-D while reducing the incidence of constipation that can occur with unopposed mu opioid receptor agonists
Note
Eluxan 75 75mg Tablet generic name is Eluxadoline. Eluxan 75 75mg Tablet is manufactured by Ziska Pharmaceuticals Ltd.Eluxan 75 is availble in all over Bangladesh.
Mes BD drug index information on Eluxan 75 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.