Dydroton 25 Tablet
Chlorthalidone
25mg
Unimed & Unihealth Manufacturers Ltd.
| Pack size | 30's Pack |
|---|---|
| Unite Price | 6.00 BDT |
Indications
Dydroton 25 Tablet is used for:
Hypertension, Oedema, Diabetes insipidus, Congestive heart failure
Adult Dose
Hypertension
25-100 mg/day PO; usual range, 12.5-25 mg/day
Edema
50-100 mg/day PO or 100 mg PO every other day; not to exceed 200 mg/day
Heart Failure
12.5-25 mg/day PO; not to exceed 100 mg/day
Child Dose
Renal Dose
Renal impairment
CrCl <10 mL/min: Ineffective; do not use
CrCl >10 mL/min: Dose adjustment not necessary
Administration
Should be taken with food. Take during meals.
Contra Indications
Severe renal impairment or anuria. Severe hepatic impairment, addison's disease, preexisting hypercalcaemia, asthma; hypersensitivity; severe allergy. Pregnancy and lactation.
Precautions
Existing fluid and electrolyte disturbances, hepatic cirrhosis, severe heart failure, hyperuricaemia, mild to moderate renal impairment. Elderly. Monitor fluid and electrolyte balance. Kidney or liver disease; diabetes; gout; hyperlipidaemia and ventricular extra systoles.
Lactation: Drug enters breast milk; not recommended (American Academy of Pediatrics states that it is "compatible with nursing")
Pregnancy-Lactation
Pregnancy
Available data over decades from observational studies and reports with chlorthalidone use in pregnant women have not identified a drug-associated risk of major birth defects or miscarriage; however, adverse fetal outcomes, including fetal or neonatal jaundice, thrombocytopenia, hypoglycemia, and electrolyte abnormalities reported following maternal use of thiazide diuretics
Drug not for use as first-line therapy to treat hypertension in pregnancy; advise pregnant women of potential risk to fetus
Hypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (eg, need for cesarean section, and post-partum hemorrhage); hypertension increases fetal risk for intrauterine growth restriction and stillbirth
Thiazides can cross placenta, and concentrations reached in umbilical vein approach those in maternal plasma; thiazides, like other diuretics, can cause placental hypoperfusion
Use of thiazides during pregnancy associated with risk of fetal or neonatal jaundice, thrombocytopenia, hypoglycemia, and electrolyte abnormalities; thiazides do not prevent or alter course of EPH (Edema, Proteinuria, Hypertension) gestosis (pre-eclampsia) and should not be used as first-line therapy to treat hypertension in pregnant women
Lactation
Drug is present in human milk; there is no information regarding effects of on breastfed infant or on milk production; because of potential for drug accumulation which may lead to serious adverse reactions in breastfed infant (such as jaundice, thrombocytopenia, hyperglycemia, electrolyte abnormalities), advise patients that breastfeeding is not recommended during therapy
Pregnancy Categories
Interactions
NSAIDs antagonise hypotensive action. Suppresses action of oral anticoagulants due to reduced prothrombin activity. Increased risk of hypokalaemia when corticosteroids are given concurrently.
Potentially Fatal: Potentiates bone marrow suppression caused by anticancer drugs. Diuretic-induced vol depletion can potentiate aminoglycoside nephrotoxicity. Impairs action of oral hypoglycaemic agents. Enhances digitalis toxicity due to hypokalaemia. vol depletion enhances lithium toxicity, conversely, sudden withdrawal of diuretics may result in subtherapeutic levels of circulating lithium. Prolonged paralysis with tubocurarine due to hypokalaemia.
Side Effects
Side effects of Chlorthalidone :
Common
Cardiovascular: Hypotension, vasculitis
Dermatologic: Photosensitivity, phototoxicity
Endocrine/metabolic: Electrolyte abnormalities, hyperglycemia, hyperuricemia
Gastrointestinal: Constipation, diarrhea, loss of appetite, nausea, vomiting
Musculoskeletal: Spasticity
Neurologic: Dizziness, headache, paresthesia
Ophthalmologic: Blurred vision, xanthopsia
Psychiatric: Restlessness
Reproductive: Impotence
Potentially Fatal: Rare. Severe hyponatraemia and idiosyncratic hypersensitivity.
Mode of Action
Chlortalidone is an oral, long acting antihypertensive/diuretic. It is a monosulfamyl diuretic that acts by enhancing the excretion of sodium and chloride ions, and water by interfering with the transport of sodium ions across the renal tubular epithelium. Their primary site of action appears to be at the cortical diluting segment in the nephron of the loop of Henle.
Note
Dydroton 25 25mg Tablet generic name is Chlorthalidone. Dydroton 25 25mg Tablet is manufactured by Unimed & Unihealth Manufacturers Ltd.Dydroton 25 is availble in all over Bangladesh.
Mes BD drug index information on Dydroton 25 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.