Durazol Suspension
Albendazole
200mg/5ml
Millat Pharmaceuticals Ltd.
| Pack size | 10 ml bot |
|---|---|
| Unite Price | 15 BDT |
Indications
Durazol Suspension is used for:
Helminthiasis, Echinococcosis, Neurocysticercosis, Enterobiasis, Ascariasis, Hookworm infections, Strongyloidiasis, Giardiasis, Filariasis
Adult Dose
Oral
Ancylostoma, Ascariasis, Hookworm, Trichostrongylus, Enterobius (Pinworm)
400 mg PO once as a single dose
Tapeworm infections
Adult: 400 mg daily on an empty stomach for 3 consecutive days.
Max: 400 mg daily; 1200 mg for 3 days.
If patient is not cured after 3 weeks, a second course of treatment is needed. In cases of Hymenolepis nana infestations, retreatment in 10-21 days is recommended.
Strogyloidiasis or taeniasis - 400 mg once daily for three consecutive days.
Giardiasis - 400 mg once daily for five days.
Hydatid disease (Echinococcosis)
Adult:
<60 kg: 15 mg/kg daily in 2 divided doses. Max: 800 mg/day.
>60 kg: 400 mg bid.
Admin dose for three 28-day cycles w/ a 14-day drug-free interval in between each cycle.
Neurocysticercosis
Adult:
<60 kg: 15 mg/kg daily in 2 divided doses (max: 800 mg/day) for 8-30 days.
>60 kg: 400 mg bid for 8-30 days.
Larva Migrans, Cutaneous & Trichuriasis
400 mg PO qDay x 3 days
Larva Migrans, Visceral
400 mg PO BID x 5 days
Fluke (Clonorchis Sinensis)
10 mg/kg PO qDay x7 days
Gnathostomiasis, Microsporidiosis
400 mg BID x 21 days
Child Dose
Child:
Usually
PO 15 mg/kg/day (max 800 mg/day) q12h
Oral
Ascariasis, Enterobiasis, Trichuriasis, Hookworm infections
Child:
1-2 years 200 mg as a single dose. OR 5 ml suspension
2 years 400 mg PO once as a single dose OR 10 ml suspension
Max: 200 mg.
Tapeworm infections
Child: >2 years: 400 mg daily on an empty stomach for 3 consecutive days.
Max: 400 mg daily; 1200 mg for 3 days.
If patient is not cured after 3 weeks, a second course of treatment is needed.
In cases of Hymenolepis nana infestations, retreatment in 10-21 days is recommended.
Renal Dose
Administration
Should be taken with food.
Contra Indications
Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.
Precautions
Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease.
Lactation: unknown, use caution.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: unknown, use caution
Interactions
Increased serum concentrations w/ dexamethasone, praziquantel and cimetidine. Decreased serum concentrations w/ aminoquinoline (antimalarials), carbamazepine, phenobarbital, and phenytoin.
Side Effects
Side effects of Albendazole :
>10%
Headache, Neurocysticercosis (11%), Hydatid disease (1.3%), Abnormal LFT, Hydatid disease (15.6%), Neurocysticercosis (<1%)
1-10%
Abdominal pain, Hydatid disease (6%), Nausea/vomiting, Hydatid disease (3.7%), Neurocysticercosis (6.2%), Dizziness/vertigo, Hydatid disease (1.2%), Neurocysticercosis (<1%), Increased intracranial pressure, Neurocysticercosis (1%), Meningeal signs, Neurocysticercosis (1%), Alopecia (reversible), Hydatid disease (1.6%), Neurocysticercosis (<1%), Fever, Hydatid disease (1%)
<1% (selected)
Rash, Urticaria, Agranulocytosis, Aplastic anemia, Bone marrow suppression, Granulocytopenia, Pancytopenia, Thrombocytopenia, Hepatitis, Acute liver failure, Acute renal failure
Potentially Fatal: Bone marrow depression.
Mode of Action
Albendazole sulfoxide (active metabolite), causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae; glycogen is depleted, glucose uptake and cholinesterase secretion are impaired and desecratory substances accumulate intracellulary. ATP production decreases, causing energy depletion, immobilisation and worm death.
Note
Durazol 200mg/5ml Suspension generic name is Albendazole. Durazol 200mg/5ml Suspension is manufactured by Millat Pharmaceuticals Ltd.Durazol is availble in all over Bangladesh.
Mes BD drug index information on Durazol Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.