Durazol Suspension

Albendazole
200mg/5ml
Millat Pharmaceuticals Ltd.
Pack size 10 ml bot
Unite Price 15 BDT

Indications

Durazol Suspension is used for: Helminthiasis, Echinococcosis, Neurocysticercosis, Enterobiasis, Ascariasis, Hookworm infections, Strongyloidiasis, Giardiasis, Filariasis

Adult Dose

Oral Ancylostoma, Ascariasis, Hookworm, Trichostrongylus, Enterobius (Pinworm) 400 mg PO once as a single dose Tapeworm infections Adult: 400 mg daily on an empty stomach for 3 consecutive days. Max: 400 mg daily; 1200 mg for 3 days. If patient is not cured after 3 weeks, a second course of treatment is needed. In cases of Hymenolepis nana infestations, retreatment in 10-21 days is recommended. Strogyloidiasis or taeniasis - 400 mg once daily for three consecutive days. Giardiasis - 400 mg once daily for five days. Hydatid disease (Echinococcosis) Adult: <60 kg: 15 mg/kg daily in 2 divided doses. Max: 800 mg/day. >60 kg: 400 mg bid. Admin dose for three 28-day cycles w/ a 14-day drug-free interval in between each cycle. Neurocysticercosis Adult: <60 kg: 15 mg/kg daily in 2 divided doses (max: 800 mg/day) for 8-30 days. >60 kg: 400 mg bid for 8-30 days. Larva Migrans, Cutaneous & Trichuriasis 400 mg PO qDay x 3 days Larva Migrans, Visceral 400 mg PO BID x 5 days Fluke (Clonorchis Sinensis) 10 mg/kg PO qDay x7 days Gnathostomiasis, Microsporidiosis 400 mg BID x 21 days

Child Dose

Child: Usually PO 15 mg/kg/day (max 800 mg/day) q12h Oral Ascariasis, Enterobiasis, Trichuriasis, Hookworm infections Child: 1-2 years 200 mg as a single dose. OR 5 ml suspension 2 years 400 mg PO once as a single dose OR 10 ml suspension Max: 200 mg. Tapeworm infections Child: >2 years: 400 mg daily on an empty stomach for 3 consecutive days. Max: 400 mg daily; 1200 mg for 3 days. If patient is not cured after 3 weeks, a second course of treatment is needed. In cases of Hymenolepis nana infestations, retreatment in 10-21 days is recommended.

Renal Dose

Administration

Should be taken with food.

Contra Indications

Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.

Precautions

Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease. Lactation: unknown, use caution.

Pregnancy-Lactation

Pregnancy Category: C Lactation: unknown, use caution

Interactions

Increased serum concentrations w/ dexamethasone, praziquantel and cimetidine. Decreased serum concentrations w/ aminoquinoline (antimalarials), carbamazepine, phenobarbital, and phenytoin.

Side Effects

Side effects of Albendazole : >10% Headache, Neurocysticercosis (11%), Hydatid disease (1.3%), Abnormal LFT, Hydatid disease (15.6%), Neurocysticercosis (<1%) 1-10% Abdominal pain, Hydatid disease (6%), Nausea/vomiting, Hydatid disease (3.7%), Neurocysticercosis (6.2%), Dizziness/vertigo, Hydatid disease (1.2%), Neurocysticercosis (<1%), Increased intracranial pressure, Neurocysticercosis (1%), Meningeal signs, Neurocysticercosis (1%), Alopecia (reversible), Hydatid disease (1.6%), Neurocysticercosis (<1%), Fever, Hydatid disease (1%) <1% (selected) Rash, Urticaria, Agranulocytosis, Aplastic anemia, Bone marrow suppression, Granulocytopenia, Pancytopenia, Thrombocytopenia, Hepatitis, Acute liver failure, Acute renal failure Potentially Fatal: Bone marrow depression.

Mode of Action

Albendazole sulfoxide (active metabolite), causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae; glycogen is depleted, glucose uptake and cholinesterase secretion are impaired and desecratory substances accumulate intracellulary. ATP production decreases, causing energy depletion, immobilisation and worm death.

Note

Durazol 200mg/5ml Suspension generic name is Albendazole. Durazol 200mg/5ml Suspension is manufactured by Millat Pharmaceuticals Ltd.Durazol is availble in all over Bangladesh. Mes BD drug index information on Durazol Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Albendazole :