Dopen Capsule
Amoxicillin
500mg
Hallmark Pharmaceuticals Ltd.
| Pack size | 50's pack |
|---|---|
| Unite Price | 6.70 BDT |
Indications
Dopen Capsule is used for:
Bacterial infections, Pharyngitis, Acute otitis media, Acute bacterial sinusitis, Endocarditis, Anthrax, Chlamydial cervicitis, Chlamydial urethritis, Lyme disease, Dental abscess, Salmonellosis,Typhoid fever, Acute Uncomplicated gonorrhea, Infections of the Lower Respiratory Tract, Skin and Skin Structure, Genitourinary Tract, Ear, Nose, Throat
Adult Dose
Adult: PO Susceptible infections 250-500 mg 8 hrly. Uncomplicated gonorrhoea W/ probenecid: 3 g as a single dose. Dental abscesses 3 g, repeat once 8 hr later.
Uncomplicated acute UTI 3 g, repeat once 10-12 hr later. Prophylaxis of endocarditis 2 or 3 g as a single dose, 1 hr before dental procedure.
Severe or recurrent resp tract infections 3 g twice daily.
H.pylori infection W/ either metronidazole or clarithromycin and a bismuth compound or an antisecretory drug: 500 mg 3 times/day.
IV/IM Susceptible infections 500 mg 8 hrly. Listerial meningitis W/ other antibiotics: 2 g 4 hrly for 10-14 days.
Child Dose
Child: PO Standard dose: 40–45 mg/kg/day q8-12h
High dose: 80–90 mg/kg/day, max 4 g/day q12h
150 mg/kg/day div q8h for penicillin-resistant S pneumoniae otitis media
Renal Dose
Renal impairment: Patients on haemodialysis should receive 250-500 mg every 24 hr and an additional dose during and after each dialysis session.
CrCl (ml/min)
10-30 250-500 mg every 12 hr.
<10 250-500 mg every 24 hr.
Administration
May be taken with or without food. May be taken w/ meals for better absorption & to reduce GI discomfort.
Contra Indications
Hypersensitivity
Precautions
Renal and hepatic disease; pregnancy, lactation; infectious mononucleosis.
Lactation: Excreted in breast milk, use caution
Pregnancy-Lactation
Pregnancy
Available data from published epidemiologic studies and pharmacovigilance case reports over several decades with amoxicillin use have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes
Animal data
No adverse developmental effects were observed in animal reproduction studies with administration of amoxicillin to pregnant mice and rats at doses up to 12.5 and 25 times the recommended human dose
Lactation
Data from a published clinical lactation study reports that amoxicillin is present in human milk; published adverse effects with amoxicillin exposure in breastfed infant include diarrhea
There are no data on effects of amoxicillin on milk production; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on breast-fed child from drug or from underlying maternal condition
Interactions
May reduce the efficacy of OC. May increase the effect of anticoagulants. Increased risk of allergic reactions w/ allopurinol. Increased and prolonged blood levels w/ probenecid. Chloramphenicol, macrolides, sulfonamides and tetracyclines may interfere w/ the bactericidal effect of amoxicillin.
Side Effects
Side effects of Amoxicillin :
Hyperactivity, agitation, insomnia, dizziness; maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis; diarrhoea, nausea, vomiting; anaemia, thrombocytopenia, leucopenia, agranulocytosis.
Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis.
Mode of Action
Amoxicillin inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis.
Note
Dopen 500mg Capsule generic name is Amoxicillin. Dopen 500mg Capsule is manufactured by Hallmark Pharmaceuticals Ltd.Dopen is availble in all over Bangladesh.
Mes BD drug index information on Dopen Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.