Dobumin Injection

Dobutamine
12.5mg/ml
ACI Limited
Pack size 1's pack
Unite Price 251.69 BDT

Indications

Dobumin Injection is used for: Heart failure, Cardiac stress test

Adult Dose

Cardiac Decompensation 0.5-1 mcg/kg/min IV continuous infusion initially, then 2-20 mcg/kg/min; not to exceed 40 mcg/kg/min Adjust according to patient's BP, heart rate, cardiac and urine output.

Child Dose

Cardiac Decompensation 0.5-1 mcg/kg/min IV continuous infusion initially, then 2-20 mcg/kg/min; not to exceed 40 mcg/kg/min

Renal Dose

Administration

IV Preparation Solution: Dilute 250 mg in 250 mL of compatible solution to yield final concentration of 1000 mcg/mL; not to exceed 5000 mcg/mL The rate of administration and the duration of therapy should be adjusted according to the patient's response, The indicators are: haemodynamic parameters such as heart rate and rhythm, arterial pressure, and, whenever possible, cardiac output and measurements of ventricular filling pressures and signs of pulmonary congestion. Because of its short half-life, Dobutamine Hydrochloride must be administered as a continuous intravenous infusion. Following the initiation of a constant rate infusion, or upon changing the rate, a steady-state dobutamine plasma concentration is achieved within approximately 10 minutes. Thus, loading doses or bolus injections are not necessary and are not recommended.

Contra Indications

Hypersensitivity; idiopathic hypertrophic subaortic stenosis (IHSS).

Precautions

Correct hypovolaemia prior to treatment. Increased risk of rapid ventricular response in patients with atrial fibrillation. Insufficient data to determine the safety and efficacy of dobutamine use after acute MI. Elderly. Neonates. Pregnancy. Lactation: Unknown whether drug is excreted into breast milk; avoid use

Pregnancy-Lactation

Pregnancy category: B Lactation: Unknown whether drug is excreted into breast milk; avoid use

Interactions

Increased cardiac output when used with nitroprusside. Increased vasopressor effect of dobutamine when used with bretylium, guanethidine, oxytocic drugs or TCAs.

Side Effects

Side effects of Dobutamine : 1-10% Tachyarrhythmia (10%), Hypertension (7.5%), Eosinophilic myocarditis (<7%), Premature ventricular beats (5%; dose related), Angina (1-3%), Dyspnea (1-3%), Fever (1-3%), Headache (1-3%), Nausea (1-3%), Palpation (1-3%) Frequency Not Defined Cardiac dysrhythmia, Exacerbation of coronary arteriosclerosis, Hypokalemia, Injection-site reactions, Syncope, 10- to 20-mm Hg increase in systolic blood pressure and increase in heart rate of 5 to 15 beats/min Potentially Fatal: Cardiac arrhythmias, allergy (rare), MI and hypotension.

Mode of Action

Dobutamine increases contractility and heart rate by stimulating ?-adrenergic receptors in the cardiac tissues.

Note

Dobumin 12.5mg/ml Injection generic name is Dobutamine. Dobumin 12.5mg/ml Injection is manufactured by ACI LimitedDobumin is availble in all over Bangladesh. Mes BD drug index information on Dobumin Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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