Dinakion Injection
Phytomenadione (Vitamin K1)
10mg/ml
Drug International Ltd.
| Pack size | 5 amps pack |
|---|---|
| Unite Price | 50.00 BDT |
Indications
Dinakion Injection is used for:
Vitamin K deficiency, Over-anticoagulation, Vitamin K deficiency bleeding
Adult Dose
Oral
Vitamin K deficiency due to drugs or malabsorption
Adult: 10-40 mg daily.
Over-anticoagulation
Adult: Up to 5 mg may be used. Dose depends on INR and degree of haemorrhage.
Intravenous
Over-anticoagulation
Adult: 0.5-5 mg via slow IV inj. Dose depends on INR and degree of haemorrhage.
Child Dose
Intramuscular
Prophylaxis of vitamin K deficiency bleeding in neonates
Child: Neonate: 0.5-1 mg, given as a single dose via IM inj.
Alternatively, 2 mg may be given orally, followed by a 2nd dose of 2 mg after 4-7 days.
Parenteral
Vitamin K deficiency bleeding in neonates
Child: Infant: 1 mg by IV/IM/SC inj, further doses may be given if necessary
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity.
Precautions
Increased risk of severe haemolytic anaemia in neonates after large doses; severe hepatic impairment; pregnancy. Premature neonates weighing <2.5 kg.
Lactation: Excreted in breast milk; use caution
Pregnancy-Lactation
Pregnancy
The drug formulation contains benzyl alcohol, which has been associated with gasping syndrome in neonates; the preservative benzyl alcohol can cause serious adverse events and death when administered intravenously to neonates and infants; if therapy is needed during pregnancy, consider using a benzyl alcohol-free formulation; published studies with the use of phytonadione during pregnancy have not reported a clear association with phytonadione and adverse developmental outcomes; there are maternal and fetal risks associated with vitamin K deficiency during pregnancy; animal reproduction studies have not been conducted with phytonadione
Pregnant women with vitamin K deficiency hypoprothrombinemia may be at an increased risk for bleeding diatheses during pregnancy and hemorrhagic events at delivery; subclinical maternal vitamin K deficiency during pregnancy has been implicated in rare cases of fetal intracranial hemorrhage
Lactation
The drug formulation contains benzyl alcohol; if available, a Preservative-Free formulation is recommended when therapy is needed during lactation; phytonadione is present in breastmilk; there are no data on effects of therapy on the breastfed child or on milk production; the developmental and health benefits of breastfeeding should be considered along with the clinical need for therapy and any potential adverse effects on breastfed child from the drug or from the underlying maternal condition
Interactions
Decreased effect of oral anticoagulants.
Side Effects
Side effects of Phytomenadione (Vitamin K1) :
Anaphylaxis, dyspnoea, cyanosis, pain, swelling, phloebitis at the Inj site, diaphoresis, dizziness, hypotension (rare), allergic reactions after SC and IM inj.
Mode of Action
Phytomenadione promotes hepatic synthesis of clotting factors. It is a naturally occurring compound that is used to prevent and treat haemorrhages related to vitamin K deficiency.
Note
Dinakion 10mg/ml Injection generic name is Phytomenadione (Vitamin K1). Dinakion 10mg/ml Injection is manufactured by Drug International Ltd.Dinakion is availble in all over Bangladesh.
Mes BD drug index information on Dinakion Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.