Indications
Dilti SR Capsule is used for:
Supraventricular tachycardia, Hypertension, Angina, Atrial fibrillation, Arrhythmias, Atrial flutter
Adult Dose
Angina
Conventional tablet: 30 mg PO q6hr; increased every 1 or 2 days until angina controlled (usually 180-360 mg/day PO divided q6-8hr); not to exceed 360 mg/day
SR: 120 mg/day PO; titrate after 7-14 days; maintenance range usually 120-320 mg/day; not to exceed 540 mg/day
Hypertension
Conventional tablet: Initial: 60-120 mg twice daily. Max: 360 mg/day.
SR: Twice-daily dosing: 60-120 mg PO q12hr; may be adjusted after 14 days; maintenance range usually 240-360 mg/day
Hepatic Impairment
Use caution
Child Dose
Renal Dose
Renal Impairment
Use caution
Administration
May be taken with or without food.
The capsules should be swallowed whole with a drink of water. They should not be crushed or chewed
Contra Indications
Sick-sinus syndrome; 2nd or 3rd ° AV block; porphyria. Severe congestive cardiac failure; marked bradycardia. Pregnancy and lactation.
Precautions
Elderly. Hepatic or renal impairment; impaired left ventricular function; prolonged AV periods; DM; hypotension. Avoid abrupt withdrawal and long-term use. Patients with sick-sinus syndrome, preexisting AV block, bradycardia and those taking beta-blockers or digitalis are at risk of developing AV block, bradycardia, asystole or sinus arrest.
Lactation: Drug enters breast milk; because of risk for serious adverse reactions in nursing infants from diltiazem, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Pregnancy-Lactation
Pregnancy category: C
Lactation: Drug enters breast milk; because of risk for serious adverse reactions in nursing infants from diltiazem, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Interactions
Increased AV blocking effect w/ clonidine. May increase serum levels of statins (e.g. atorvastatin, lovastatin), carbamazepine, phenytoin. May increase bradycardic affect of amiodarone, digoxin, mefloquine. May enhance antihypertensive effect w/ other antihypertensives (e.g. aldesleukin), antipsychotic. Increased serum levels w/ cimetidine. Decreased serum levels w/ rifampicin, phenobarbital.
Potentially Fatal: IV: May enhance hypotensive effect of IV ?-blockers.
Side Effects
Side effects of Diltiazem Hydrochloride :
>10%
Edema (2-15%), Headache (5-12%)
1-10%
Dizziness (3-10%), AV block (2-8%), Peripheral edema (2-8%), Bradyarrhythmia (2-6%), Headache (1-5%), Hypotension (2-4%), Nausea (3%), Vomiting (2%), Vasodilation (2-3%), Extrasystoles (2%), Flushing (1-2%), Drug-induced gingival hyperplasia (<2%), Myalgia (2%), Diarrhea (1-2%), Constipation (2-4%), Bronchitis (1-4%), Sinus congestion (1-2%), Dyspnea (1-6%), Congestion (1-2%)
< 1%
Increased Alkaline phosphatase as well as ALT and AST, CHF, Thrombocytopenia, Toxic epidermal necrolysis, Hemolytic anemia, Photosensitivity, Extrapyramidal symptoms, Syncope
Mode of Action
Diltiazem relaxes coronary vascular smooth muscles by inhibiting influx of calcium ions during depolarisation of the vascular smooth muscles and myocardium. It increases myocardial O2 delivery in patients with vasospastic angina and inhibits cardiac conduction, particularly at the SA and AV nodes.
Note
Dilti SR 90mg Capsule generic name is Diltiazem Hydrochloride. Dilti SR 90mg Capsule is manufactured by Edruc Ltd.Dilti SR is availble in all over Bangladesh.
Mes BD drug index information on Dilti SR Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.