Diclox Capsule
Dicloxacillin
250mg
Novartis (Bangladesh) Ltd.
| Pack size | 40's pack |
|---|---|
| Unite Price | 242 BDT |
Indications
Diclox Capsule is used for:
Pneumonia, Endocarditis, Impetigo, Cellulitis, Septic Arthritis, Surgical Prophylaxis, Otitis externa, Staphylococcal skin infections, Folliculitis, Boils, Carbuncles, Mastitis, Osteomyelitis, Throat infections, Streptococcus Septicaemia
Adult Dose
Oral
Staphylococcus aureus infections
125-500 mg PO q6hr
Child Dose
Child: PO 12–25 mg/kg/day q6h
For bone and joint infections, up to 100 mg/kg/day
Renal Dose
Administration
Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before or 2 hr after meals.
Contra Indications
Hypersensitivity to penicillins.
Precautions
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Skin sensitization may occur on direct contact. Monitor serum K concentration, renal and hematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route; elderly; porphyria.
Lactation: excreted in breast milk, use caution
Pregnancy-Lactation
Pregnancy Category: B
Lactation: excreted in breast milk, use caution
Interactions
Probenecid prolongs serum levels of dicloxacillin. Bacteriostatic drugs (e.g. chloramphenicol, tetracyclines) may antagonise the bactericidal effect of dicloxacillin. May reduce anticoagulant response to dicumarol and warfarin. May increase risk of methotrexate toxicity. May diminish the effect of live vaccines (e.g. typhoid vaccine).
Side Effects
Side effects of Dicloxacillin :
1-10%
Abdominal pain, Diarrhea, Nausea
<1%
Anemia, Elevated LFTs, Fever, Hypersensitivity, Nephritis, Pseudomembranous colitis, Seizures with extremely high doses &/or renal failure, Rash (maculopapular to exfoliative), Vomiting, Vaginitis
Potentially Fatal: Anaphylaxis.
Mode of Action
Dicloxacillin has antimicrobial action similar to benzylpenicillin and includes penicillinase-producing and non-penicillinase-producing staphylococci. It is active against streptococci eg, S. pneumoniae and S. pyogenes is < that of benzylpenicillin, but sufficient to be useful when these organisms are present with penicillin-resistant staphylococci. It is ineffective against E. faecalis.
Note
Diclox 250mg Capsule generic name is Dicloxacillin. Diclox 250mg Capsule is manufactured by Novartis (Bangladesh) Ltd.Diclox is availble in all over Bangladesh.
Mes BD drug index information on Diclox Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.