Indications
Diaset 50 Tablet is used for:
Type 2 DM
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: Initially, 25 mg tid. Increase if necessary after 4-8 wk to 50 mg tid and continue for 3 mth. Max: 100 mg tid.
Hepatic Impairment
No admustment necessary
Child Dose
Safety & efficacy not established
Renal Dose
Renal Impairment
Mild-moderate impairment: No dosage adjustment
Severe impairment: Not recommended
Administration
Should be taken with food. Take w/ 1st bite of each main meal.
Contra Indications
Patient w/ diabetic ketoacidosis, inflammatory bowel disease, colonic ulceration, partial intestinal obstruction or predisposition to this condition, chronic intestinal diseases associated w/ marked disorders of digestion or absorption and co-existing conditions that may deteriorate as a result of increased intestinal gas formation.
Precautions
Patient exposed to stress (e.g. fever, trauma, infection, surgery). Renal impairment. Pregnancy and lactation. Patient Counselling Adhere to diet and exercise regimen. Monitoring Parameters Periodic monitoring of blood glucose tests. Measure glycosylated Hb to monitor long term glycaemic control.
Lactation: Enters slightly into breast milk; nor recommended
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Enters slightly into breast milk; nor recommended
Interactions
Concomitant use w/ insulin increases the risk of hypoglycaemia. Intestinal adsorbents (e.g. charcoal) and carbohydrate-splitting digestive enzyme supplements (e.g. amylase, pancreatin) may reduce glycaemic effects. May significantly reduce the bioavailability of ranitidine and propranolol.
Side Effects
Side effects of Miglitol :
>10%
Flatulence (42%), Diarrhea (29%), Abdominal pain (12%)
1-10%
Rash (4.3%)
Frequency Not Defined
Low serum iron
Mode of Action
Miglitol reversibly inhibits membrane-bound intestinal ?-glucosidase enzymes which hydrolyse oligosaccharides and disaccharides to glucose and other monosaccharides in the small intestinal brush border. It delays carbohydrate breakdown, glucose absorption and reduces postprandial hyperglycaemia.
Note
Diaset 50 50mg Tablet generic name is Miglitol. Diaset 50 50mg Tablet is manufactured by ACI LimitedDiaset 50 is availble in all over Bangladesh.
Mes BD drug index information on Diaset 50 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.