Detomax Injection
Dexmedetomidine
200 mcg/2 ml
Incepta Pharmaceuticals Ltd.
| Pack size | |
|---|---|
| Unite Price | 400.00 BDT |
Indications
Detomax Injection is used for:
ICU Sedation, Fiberoptic Intubation, Procedural Sedation
Adult Dose
ICU Sedation
Load: 1 mcg/kg IV over 10 minutes
Maintenance 0.2-1.4 mcg/kg/hr IV
Titrate less frequently than q30min to prevent hypotension
Fiberoptic Intubation
Load: 1 mcg/kg IV over 10 minutes
Maintenance 0.7 mcg/kg/hr IV
Procedural Sedation
Load: 1 mcg/kg IV over 10 minutes
Maintenance 0.6 mcg/kg/hr IV titrate to effect (usually 0.2-1 mcg/kg/hr)
Titrate less frequently than q30min to prevent hypotension
Hepatic Impairment
Dose reduction may be required
Child Dose
Safety and efficacy not established
Renal Dose
Renal Impairment
Dose reduction may be required
Administration
IV Preparation
Dilute in NS
IV Administration
Infuse loading dose over 10 min
Contra Indications
2nd or 3rd degree AV block (unless paced), uncontrolled hypotension, acute cerebrovascular disorders.
Precautions
Significant CV dysfunction, advanced heart block &/or severe ventricular dysfunction, hypovolemia, DM, chronic HTN. Renal & hepatic impairment. Do not inj by bolus or rapid IV. Do not administer for >24 hr.
Pregnancy & lactation. Elderly. Childn <18 yr.
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Pregnancy
There are no adequate and well-controlled studies of use in pregnant women
In an in vitro human placenta study, placental transfer of dexmedetomidine occurred
Animal studies
In pregnant rats, dexmedetomidine placental transfer observed when radiolabeled dexmedetomidine was administered SC
Thus, fetal exposure should be expected in humans; use during pregnancy only if potential benefits justify potential fetal risk
Lactation
Unknown if excreted in human milk
Radio-labeled dexmedetomidine administered SC to lactating female rats was excreted in milk
Because many drugs are excreted in human milk, caution should be exercised when administered to breastfeeding women
Interactions
Enhanced pharmacologic effects of anaesth, sedatives, hypnotics, opiate agonists, other vasodilators or drugs that have negative chronotropic effects (e.g. cardiac glycosides).
Side Effects
Side effects of Dexmedetomidine :
>10%
Hypotension (28%)
1-10%
AFib.Anemia, Bradycardia, Fever, Pleural effusion, Leukocytosis, Pulmonary edema
Mode of Action
Centrally acting alpha2-adrenoceptor agonist that has sedative and anesthetic properties possibly by activating G-proteins in the brainstem, which results in the inhibition of norepinephrine release.
Note
Detomax 200 mcg/2 ml Injection generic name is Dexmedetomidine. Detomax 200 mcg/2 ml Injection is manufactured by Incepta Pharmaceuticals Ltd.Detomax is availble in all over Bangladesh.
Mes BD drug index information on Detomax Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.