Indications
Desgud Tablet is used for:
Itching, Sneezing, Watery eyes, Allergic conditions, Runny nose, Hives, Skin rash, Common cold
Adult Dose
Oral
Allergic conditions
Adult: 5 mg once daily.
Hepatic Impairment: Initially, 5 mg every other day.
Child Dose
Oral
Allergic conditions
Child: 12 years or over : 5 mg once daily.
Child 6-11 years : 2.5 mg once daily.
Child 12 months-5 years : 1.25 mg (2.5 ml syrup) once daily.
Child 6 months-11 months : 1 mg (2 ml syrup) once daily.
Renal Dose
Initially, 5 mg every other day.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity.
Precautions
Severe renal or hepatic failure; children <6 mth, elderly, epilepsy, pregnancy and lactation.
Lactation: excretion in milk unknown/not recommended
Pregnancy-Lactation
Pregnancy
The limited available data in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage; there are no adequate and well-controlled studies in pregnant women
Reproductive potential
There are no data available on human infertility associated with desloratadine
Female: There were no clinically relevant effects of desloratadine on female fertility in rats
Male: A male specific decrease in fertility occurred at an oral desloratadine dose of ?12 mg/kg in rats (approximately 65 times the RHD); male fertility was unaffected at a desloratadine dose of 3 mg/kg (approximately 10 times the RHD)
Lactation
Desloratadine and pseudoephedrine both pass into breast milk; there are no sufficient data on effects of desloratadine on breastfed infant or effects of desloratadine on milk production
The decision should be made whether to discontinue nursing or to discontinue drug, taking into account developmental and health benefits of breastfeeding, the nursing mother’s clinical need, and any potential adverse effects on breastfed infant from therapy or from underlying maternal condition
Interactions
Potential increase in plasma concentrations w/ drugs affecting hepatic microsomal enzymes (e.g. azithromycin, cimetidine, erythromycin, fluoxetine, ketoconazole).
Side Effects
Side effects of Desloratadine :
>10%
Headache (14%), Fever (12%), Irritability (12%), Diarrhea (15%), Upper respiratory infection (11%), Cough (11%)
1-10%
Dizziness (4%), Somnolence (2%), Dizziness (4%), Fatigue (2%), Erythema (2%), Macupopular rash (3%), Dysmenorrhea (2%), Urinary tract infection (4%), Bronchitis (6%), Epistaxis (3%)
Mode of Action
Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Note
Desgud 5mg Tablet generic name is Desloratadine. Desgud 5mg Tablet is manufactured by Leon Pharmaceuticals Ltd.Desgud is availble in all over Bangladesh.
Mes BD drug index information on Desgud Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.