Dayprox Tablet
Oxaprozin
600mg
Eskayef Pharmaceuticals Ltd.
| Pack size | 30's pack |
|---|---|
| Unite Price | 7.00 BDT |
Indications
Dayprox Tablet is used for:
Rheumatoid arthritis, Osteoarthritis, Juvenile rheumatoid arthritis
Adult Dose
Osteoarthritis
Initial in mild to moderate disease: 600mg PO qDay
Usual in moderate to severe disease: 1200mg PO qDay
Maximum 1,800 mg/day or 26 mg/kg/day, whichever is lower, divided PO q12hr
Rheumatoid Arthritis
1200mg PO qDay (individualize)
Maximum 1,800 mg/day or 26 mg/kg/day, whichever is lower, divided PO q12hr
Hepatic Impairment
Caution in patients with severe liver impairment
Child Dose
Juvenile Rheumatoid Arthritis
<6 years
Safety and efficacy not established
>6 years
22-31 kg: 600 mg PO qDay
32-54 kg: 900 mg PO qDay
>55 kg: 1200 mg PO qDay
Renal Dose
Renal Impairment
Severe renal impairment or on dialysis: 600 mg PO qDay; may increase to 1200 mg/day; monitor closely
Administration
Take with food or water to avoid GI effects
Contra Indications
Previous or active peptic ulceration, known hypersensitivity to NSAIDs. Perioperative pain in CABG setting.
Precautions
Be alert for ulceration and bleeding in patients treated chronically. History of serious GI events, alcoholism, smoking, other factors known to be associated with peptic ulcer. Elderly or debilitated patients. Uncompensated cardiac failure, history of hypertension, cardiac decompensation, chronic diuretic therapy, conditions predisposing to fluid retention. Renal and hepatic impairment. Underlying coagulation defects or patients who are undergoing surgical procedures where a high degree of haemostasis is required. Pregnancy (avoid in 3rd trimester) and lactation.
Lactation: not known whether excreted in breast milk; effect on infant unknown
Pregnancy-Lactation
Pregnancy Category: C; D in 3rd trimester or near delivery.
Interactions
Increased risk of salicylate toxicity with aspirin. May increase effects of oral anticoagulants. May reduce effects of beta-blockers, diuretics and other antihypertensive agents. May increase risk of methotrexate and lithium toxicity.
Side Effects
Side effects of Oxaprozin :
Common
Edema, Rash, Abdominal pain, Anorexia, Constipation, Diarrhea, Indigestion, Nausea/Vomiting, GI ulcer, Gross bleeding with perforation, Heartburn, Anemia, LFT's increased.Tinnitus, Dysuria, Increased frequency of urination, Myocardial infarction (<2%)
<1%
Hypertension (<1%), Palpitations (<1%), Thrombotic tendency observations, Erythema multiforme (rare), Scaling eczema, Stevens-Johnson syndrome (rare), Toxic epidermal necrolysis (rare), Cerebrovascular accident, Gastrointestinal hemorrhage (<1%), Agranulocytosis (rare), Leukopenia (<1%), Thrombocytopenia (<1%), Hepatitis (rare), Jaundice, Liver failure, Anaphylactoid reaction (<1%), Amblyopia (<1%), Hearing loss (<1%), Acute renal failure (rare), Hematuria (rare), Interstitial nephritis (rare), Bronchospasm, Serum sickness due to drug (rare)
Potentially Fatal: Anaphylactoid reactions, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, severe hepatic reactions.
Mode of Action
Oxaprozin is a propionic acid derivative NSAID. It inhibits the enzyme cyclooxygenase resulting in the blockage of prostaglandin synthesis.
Note
Dayprox 600mg Tablet generic name is Oxaprozin. Dayprox 600mg Tablet is manufactured by Eskayef Pharmaceuticals Ltd.Dayprox is availble in all over Bangladesh.
Mes BD drug index information on Dayprox Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.