Darvoni Tablet
Sofosbuvir + Daclatasvir
400 mg + 60 mg
Beacon Pharmaceuticals Ltd.
| Pack size | 6's pack |
|---|---|
| Unite Price | 1000.00 BDT |
Indications
Darvoni Tablet is used for:
Sofosbuvir and Daclatasvir combination indicated for the treatment of, chronic hepatitis C (CHC) infection, as a component of a combination antiviral treatment regimen.
Sofosbuvir and Daclatasvir combination should be used in combination with or without ribavirin for the treatment of CHC in adults.
Adult Dose
Oral
Adult
Tablet: 1 tab once daily.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment (any degree): No dose adjustment required
Administration
Can be taken with or without food.
Contra Indications
When Sofosbuvir and Daclatasvir is used in combination with Ribavirin, the contraindications applicable to those agents are applicable to combination therapies.
Sofosbuvir and Daclatasvir combination treatment with Ribavirin is contraindicated in women who are pregnant or may become pregnant and men whose female partners are pregnant because of the risks for birth defects and fetal death associated with Ribavirin.
Precautions
Pregnancy: If Ribavirin is used with this combination it may cause birth defects and fetal death and animal studies have shown interferons have abortifacient effects; avoid pregnancy in female patients and female partners of male patients. Patients must have a negative pregnancy test prior to initiating therapy, use at least 2 effective non-hormonal methods of contraception and have monthly pregnancy tests.
Pregnancy-Lactation
Interactions
Reduced therapeutic effect w/ drugs that are potent P-gp inducers in the intestine (eg rifampicin, St. John's wort, carbamazepine & phenytoin), modafinil, phenobarb/oxcarbazepine, rifabutin/rifapentine. P-gp &/or BCRP inhibitors. May result in serious symptomatic bradycardia when co-administered w/ amiodarone in combination w/ another direct acting antiviral.
Side Effects
Side effects of Sofosbuvir + Daclatasvir :
The most common adverse events observed with Sofosbuvir and Daclatasvir in combination with Ribavirin were fatigue and headache.
There are some rare side effects, such as Insomnia, Nausea, Pruritus, Anemia, Asthenia, Rash, Anorexia, Chills, Infulenza Like Illness
Mode of Action
Daclatasvir
Inhibits NS5A, a nonstructural protein encoded by HCV.
Binds to the N-terminus within domain 1 of NS5A, which may cause structural distortions that interfere with NS5A functions, and thereby inhibits both viral RNA replication and virion assembly.
Sofosbuvir
Nucleotide prodrug that undergoes metabolism to the active uridine analog triphosphate, an inhibitor of HCV NS5B RNA-dependent polymerase; its inhibition in turn suppresses viral replication .
Note
Darvoni 400 mg + 60 mg Tablet generic name is Sofosbuvir + Daclatasvir. Darvoni 400 mg + 60 mg Tablet is manufactured by Beacon Pharmaceuticals Ltd.Darvoni is availble in all over Bangladesh.
Mes BD drug index information on Darvoni Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.