Indications
Dapsomed 100 Tablet is used for:
Pneumonia, Acne, Leprosy, Dermatitis herpetiformis
Adult Dose
Dermatitis Herpetiformis
50 mg PO qDay, titrate to 300 mg qDay or higher to achieve desired effect
Reduce dose to minimum effective dose within the range of 50-300 mg qDay as soon as possible
Leprosy
100 mg PO qDay, in combination with other antileprosy drugs
Tuberculoid or Lepromatous Disease
100 mg PO qDay with rifampin 600 mg PO qDay
Child Dose
Child: PO 2 mg/kg, max 100 mg q24h
4 mg/kg, max 200 mg Once weekly
Renal Dose
Administration
Contra Indications
Hypersensitivity. Severe anaemia, porphyria.
Precautions
G6PD deficiency, methaemoglobin or Hb M. Perform regular blood counts and monitor liver function regularly. Pregnancy and lactation.
Lactation: Enters breast milk; not recommended (AAP Committee states "compatible with nursing")
Pregnancy-Lactation
Pregnancy category: C
Lactation: Enters breast milk; not recommended (AAP Committee states "compatible with nursing")
Interactions
Decreased serum conc of dapsone when used with rifampicin. Increased plasma conc with probenecid, trimethoprim. Antagonize clofazimine.
Side Effects
Side effects of Dapsone :
1-10%
Hemolysis, Methemoglobinemia
<1%
Reactional states (ie, abrupt changes in clinical activity occurring during any leprosy treatment; classified as reversal of erythema nodosum leprosum reactions), Insomnia, Headache, Exfoliative dermatitis, Photosensitivity, Nausea, Vomiting, Anemia, Leukopenia, Agranulocytosis, Hepatitis, Cholestatic jaundice, Peripheral neuropathy (usually in nonleprosy patients), Blurred vision, Tinnitus, SLE
Potentially Fatal: Agranulocytosis, serious cutaneous hypersensitivity reactions, exfoliative dermatitis.
Mode of Action
Dapsone inhibits folic acid synthesis by preventing normal bacterial utilization of PABA (PABA).
Note
Dapsomed 100 100 mg Tablet generic name is Dapsone. Dapsomed 100 100 mg Tablet is manufactured by MedRx Life Science Ltd.Dapsomed 100 is availble in all over Bangladesh.
Mes BD drug index information on Dapsomed 100 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.