Danlene 25 Capsul
Dantrolene Sodium
25mg
Incepta Pharmaceuticals Ltd.
| Pack size | 30's pack |
|---|---|
| Unite Price | 10.00 BDT |
Indications
Danlene 25 Capsul is used for:
Muscle tightness, muscle cramping (spasms), muscle pain caused by spinal cord injury, stroke, cerebral palsy, multiple sclerosis.
Adult Dose
Oral
Spasticity
Adult: Initially, 25 mg daily increased gradually at 7-day intervals over 7 wk. Discontinue if no response after 45 days of treatment. Max: 100 mg 4 times daily.
Child Dose
Oral
Spasticity
Child: Initially, 0.5 mg/kg once daily, may increase gradually to 2 mg/kg 3-4 times daily. Max: 100 mg 4 times daily.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Active liver disease; acute muscle spasm; patients who use their spasticity to maintain posture or function. Lactation.
Precautions
Perform LFTs before and during treatment. Increased risk of liver injury in patients >30 yr, female patients especially those on oestrogen therapy, history of liver disease or patients with daily dose >400 mg. Cardiac or pulmonary disorders. Pregnancy.
Lactation: enters breast milk/not recommended
Pregnancy-Lactation
Pregnancy Category: C
Lactation: enters breast milk/not recommended
Interactions
CNS depressants; oestrogens; calcium-channel blockers. CNS effects enhanced by alcohol or CNS depressants.
Side Effects
Side effects of Dantrolene Sodium :
Fatigue, muscle weakness/pain. GI disturbances, CNS effects, tachycardia, unstable BP, dyspnoea, drowsiness, rashes, pruritus, chills and fever, visual disturbances, dysphagia, speech disturbances; haematuria, crystalluria, urinary frequency, retention and incontinence. Increased serum AST (SGOT), ALT (SGPT), alkaline phosphatase, LDH, BUN, and total serum bilirubin concentrations, Difficult erection, Abnormal hair growth, Aplastic anemia, Anemia, Leukopenia, Lymphoma, Thrombocytopenia
Potentially Fatal: Hepatotoxicity, pleural effusion with pericarditis.
Mode of Action
Dantrolene has a direct action on skeletal muscle. It uncouples muscular contraction from excitation, probably by interfering with calcium release from sarcoplasmic reticulum.
Note
Danlene 25 25mg Capsul generic name is Dantrolene Sodium. Danlene 25 25mg Capsul is manufactured by Incepta Pharmaceuticals Ltd.Danlene 25 is availble in all over Bangladesh.
Mes BD drug index information on Danlene 25 Capsul is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.