Cyclorin Eye Drops
Cyclosporine Eye prep
50 mg/100 ml
Ibn Sina Pharmaceutical Ind. Ltd.
| Pack size | 5 ml drop |
|---|---|
| Unite Price | 210.00 BDT |
Indications
Cyclorin Eye Drops is used for:
Dry eye, Keratoconjunctivitis Sicca,
This drug is indicated to increase tear production in patients whose tear production is suppressed due to ocular inflammation associated with dry eye syndrome (keratoconjunctivitis sicca).
Adult Dose
Keratoconjuntivitis Sicca
1 drop twice daily approximately 12 hours apart in each eye
May be used with artificial tears; allow 15-minute interval between products
Child Dose
<16 years
Safety and efficacy not established
>16 years
Keratoconjuntivitis Sicca
1 drop twice daily approximately 12 hours apart in each eye
May be used with artificial tears; allow 15-minute interval between products
Renal Dose
Administration
Contra Indications
Cyclosporine is contraindicated in patients with active ocular infections and in patients with known or suspected hypersensitivity to any of the ingredients in the formulation.
Precautions
Cyclosporine eye drop should not be administered while wearing contact lenses. Patients with decreased tear production typically should not wear contact lenses. If contact lenses are worn, they should be removed prior to the administration of this formulation. Lenses may be reinserted 15 minutes following administration of Cyclosporine eye drop.
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Pregnancy
Clinical administration of cyclosporine ophthalmic emulsion 0.05% is not detected systemically following topical ocular administration, and maternal use is not expected to result in fetal exposure to the drug
Oral administration of cyclosporine to pregnant rats or rabbits did not produce teratogenicity at clinically relevant doses
Lactation
Cyclosporine is known to appear in human milk following systemic administration, but presence in human milk following topical treatment has not been investigated; although blood concentrations are undetectable following topical administration of cyclosporine ophthalmic, caution should be exercised when cyclosporine ophthalmic multidose is administered to a nursing woman; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for cyclosporine ophthalmic multidose and potential adverse effects on the breast-fed child from cyclosporine
Interactions
Increased ciclosporin level by diltiazem, doxycycline, erythromycin, ketoconazole, methylprednisolone (high doses), nicardipine, verapamil, oral contraceptives. Drugs which reduce ciclosporin level are carbamazepine, isoniazid, phenobarbitone, phenytoin and rifampicin. Increased risk of convulsion when used concurrently with high-dose methylprednisolone.
Potentially Fatal: Additive nephrotoxicity when used with aminoglycosides, amphotericin B, ciprofloxacin, colchicine, melphalan, co-trimoxazole and NSAIDs.
Side Effects
Side effects of Cyclosporine Eye prep :
>10%
Ocular burning (17%)
Frequency Not Defined
Conjunctival hyperemia, Discharge, Epiphora, Eye pain, Foreign body sensation, Pruritus
Mode of Action
Ciclosporin is a strong immunosuppressant that acts mainly on the helper T-cells. It inhibits the activation of calcineurin and production of interleukin-2, thus reducing cell-mediated immune response. May act as immunomodulator to suppress tear production in keratoconjunctivitis sicca
Note
Cyclorin 50 mg/100 ml Eye Drops generic name is Cyclosporine Eye prep. Cyclorin 50 mg/100 ml Eye Drops is manufactured by Ibn Sina Pharmaceutical Ind. Ltd.Cyclorin is availble in all over Bangladesh.
Mes BD drug index information on Cyclorin Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.