Compimet 850 Tablet
Metformin Hydrochloride + Pioglitazone
850 mg + 15 mg
Incepta Pharmaceuticals Ltd.
| Pack size | 30's pack |
|---|---|
| Unite Price | 11 BDT |
Indications
Compimet 850 Tablet is used for:
Type 2 DM
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: Tab contains pioglitazone 15 mg and metformin 500 mg or 850 mg:
Initially, 15 mg/500 mg bid or 15 mg/850 mg once daily.
Patients inadequately controlled on metformin monotherapy: Initially, 15 mg/500 mg bid or 15 mg/850 mg 1-2 times daily, depending on current metformin dose.
Patients inadequately controlled on pioglitazone monotherapy: Initially, 15 mg/500 mg bid or 15 mg/850 mg once daily.
Max: Pioglitazone 45 mg and metformin 2,550 mg daily.
Hepatic impairment: Contraindicated.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
Obtain eGFR before starting metformin
eGFR <30 mL/min/1.73 m²: Contraindicated
eGFR 30-45 mL/min/1.73 m²: Not recommended to initiate treatment
Monitor eGFR at least annually or more often for those at risk for renal impairment (eg, elderly)
If eGFR falls below 45mL/min/1.73 m² while taking metformin, risks and benefits of continuing therapy should be evaluated
If eGFR falls below 30 mL/min/1.73 m²: while taking metformin, discontinue the drug
Administration
Contra Indications
Renal disease or renal dysfunction (e.g. as suggested by serum creatinine levels >1.5 mg/dl in male, >1.4 mg/dl in females or abnormal creatinine clearance), which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction and septicemia.Current or history of cardiac failure, active or history of bladder cancer,
Known hypersensitivity to Pioglitazone, Metformin or any other component of this combination.
Acute or chronic metabolic acidosis including diabetic ketoacidosis with or without coma.
Precautions
Patient w/ oedema, anaemia. Premenopausal, anovulatory women. Pregnancy. Patient Counselling This drug may cause visual disturbance, if affected, do not drive or operate machinery. Monitoring Parameters Monitor HbA1c, serum glucose; signs and symptoms of oedema or heart failure, bladder cancer; liver enzymes, haematologic parameters, renal function; vit B12 and folate if anaemia is present. Routine ophth examination.
Lactation: not known if crosses into breast milk, avoid using in nursing women
Pregnancy-Lactation
Pregnancy: Limited data with metformin/pioglitazone or pioglitazone in pregnant women are not sufficient to determine a drug-associated risk for major birth defects or miscarriage; poorly controlled diabetes in pregnancy increases maternal risk for diabetic ketoacidosis, pre-eclampsia, spontaneous abortions, preterm delivery, still birth and delivery complications; poorly controlled diabetes increases fetal risk for major birth defects, still birth, and macrosomia related morbidity
Lactation: There is no information regarding the presence of metformin/pioglitazone or pioglitazone in human milk; effects on breastfed infant, or effects on milk production; there is insufficient information on effects of metformin on breastfed infant and no available information on effects of metformin on milk production; developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on the breastfed infant from metformin/pioglitazone or from underlying maternal condition
Interactions
Additive effect w/ sulfonylureas. Thiazide diuretics, corticosteroids, phenothiazines, OC, sympathomimetics, niacin, Ca channel blockers and isoniazid may exacerbate loss of glycaemic control. ACE inhibitors may reduce fasting blood glucose concentrations. May increase serum level w/ cimetidine.
Potentially Fatal: Concurrent use w/ iodinated contrast agents may increase the risk of metformin-induced lactic acidosis.
Side Effects
Side effects of Metformin Hydrochloride + Pioglitazone :
>10%
Lower limb edema (2.9-11.3%), Upper respiratory infection (12-16)
1-10%
Weight gain (2.9-6.7%), Diarrhea (4.8-5.8%), Nausea (3.6-5.8%), Urinary tract infection (5.3-5.8%), Dizziness (4.8-5.4%), Headache (4.6-5.3%), Sinusitis (4.4-5%), Edema (3%)
Mode of Action
Pioglitazone is as a potent and highly selective agonist for the peroxisome proliferator activated receptor-gamma. Activation of these receptors promotes the production of gene products involved in lipid and glucose metabolism. It also improves insulin response to target cells witho increasing the pancreatic secretion of insulin.
Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).
Note
Compimet 850 850 mg + 15 mg Tablet generic name is Metformin Hydrochloride + Pioglitazone. Compimet 850 850 mg + 15 mg Tablet is manufactured by Incepta Pharmaceuticals Ltd.Compimet 850 is availble in all over Bangladesh.
Mes BD drug index information on Compimet 850 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.