Combocef 100 Tablet
Cefpodoxime + Clavulanic Acid
100mg + 62.5mg
ACI Limited
| Pack size | 12's Pack |
|---|---|
| Unite Price | 30.09 BDT |
Indications
Combocef 100 Tablet is used for:
Pharyngitis, Acute otitis media, Community-acquired pneumonia, Sinusitis, UTI, Cystitis, Gonorrhea, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis, Enteric fever
Adult Dose
Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Acute Maxillary Sinusitis
200 mg PO q12hr for 10 days
Acute Community-Acquired Pneumonia
200 mg PO q12hr for 14 days
Pharyngitis/Tonsillitis
100 mg PO q12hr for 5-10 days
Skin/Skin Structure Infections
200-400 mg PO q12hr for 7-14 days
Uncomplicated gonorrhoea
200 mg as a single dose
Uncomplicated Urinary Tract Infections
100 mg PO q12hr for 7-14 days
Complicated urinary tract infections
200 mg PO 12 hourly for 7 days
Hepatic impairment
Dosage adjustment not necessary
Child Dose
Child : PO 10 mg/kg/day, max 400 mg/day q12h
6 months - 2 years : 40 mg every 12 hours
3 - 8 years : 80 mg every 12 hours
over 9 years : 100 mg every 12 hours
Renal Dose
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min) Dosage Recommendation
10-39 Increase dosing intervals to 24 hrly.
<10 Increase dosing intervals to 48 hrly.
Administration
Should be taken with food. Take after meals.
Contra Indications
Hypersensitivity.
Precautions
History of allergy to penicillin; severe renal impairment; pregnancy and lactation.
Lactation: Drug excreted in breast milk in low concentrations; not recommended
Pregnancy-Lactation
Interactions
Antacids or H2-blockers may decrease the absorption of cefpodoxime. Reduced renal excretion w/ probenecid.
Side Effects
Side effects of Cefpodoxime + Clavulanic Acid :
>10%
Diarrhea in infants and toddlers (15.4%), Diaper rash (12.1%)
1-10%
Diarrhea (7.4%), Nausea (3.8%), Vaginal infection (3.1%), Vomiting (1.1-2.1%), Abdominal pain (1.6%), Rash (1.4%), Headache (1.1%)
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
Mode of Action
Cefpodoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Addition of clavulanate inhibits beta-lactamase-producing bacteria; Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate Cefpodoxime by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with Cefpodoxime extends the antibacterial spectrum of Cefpodoxime to include many bacteria normally resistant to Cefpodoxime and other penicillins and cephalosporins.
Note
Combocef 100 100mg + 62.5mg Tablet generic name is Cefpodoxime + Clavulanic Acid. Combocef 100 100mg + 62.5mg Tablet is manufactured by ACI LimitedCombocef 100 is availble in all over Bangladesh.
Mes BD drug index information on Combocef 100 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.