Combipen 4 LAC Injection
Benzyl Penicillin + Procaine Penicillin
300k+100k units per Vial
Acme Laboratories Ltd.
| Pack size | 5 vials pack |
|---|---|
| Unite Price | 17.19 BDT |
Indications
Combipen 4 LAC Injection is used for:
Meningitis, Peritonitis, Anthrax, Non-gonococcal urethritis, Diphtheria, Syphilis, Infections caused by Staphylococcus (susceptible strains), Streptococcus, Pneumococcus species gonorrhoea, Subacute bacterial endocarditis, Upper respiratory tract, Erysipelas, Skin and soft tissue infections, Moderately severe pneumonia and otitis media, Empyema, Bacteremia, Pericarditis, Arthritis
Adult Dose
Streptococcal Infections Group A-Infections of the upper-respiratory tract, skin and soft-tissue infections, scarlet fever, and erysipelas.
The following doses are recommended:
Adult patients over 60 lbs. in weight: 2,400,000 units.
NOTE: Treatment with the recommended dosage is usually given at a single session using multiple IM sites when indicated. An alternative dosage schedule may be used, giving one-half (1/2) the total dose on day 1 and one-half (1/2) on day 3.
Pneumococcal Infections (except pneumococcal meningitis)
1,200,000 units in adults, repeated every 2 or 3 days until the temperature is normal for 48 hours. Other forms of penicillin may be necessary for severe cases.
Child Dose
Streptococcal Infections Group A-Infections of the upper-respiratory tract, skin and soft-tissue infections, scarlet fever, and erysipelas.
The following doses are recommended:
Pediatric patients over 60 lbs. in weight: 2,400,000 units.
Pediatric patients from 30 to 60 lbs.: 900,000 units to 1,200,000 units.
Pediatric patients under 30 lbs.: 600,000 units.
NOTE: Treatment with the recommended dosage is usually given at a single session using multiple IM sites when indicated. An alternative dosage schedule may be used, giving one-half (1/2) the total dose on day 1 and one-half (1/2) on day 3.
Pneumococcal Infections (except pneumococcal meningitis)
600,000 units in pediatric patients, repeated every 2 or 3 days until the temperature is normal for 48 hours. Other forms of penicillin may be necessary for severe cases.
Renal Dose
Renal Impairment
CrCl 10-50 mL/min: Decrease dose by 25%
CrCl <10 mL/min: Decrease dose by 50-70%
Hemodialysis: Removed by hemodialysis; administer after dialysis
Administration
IM/IV Administration
Do not inject near artery or nerve (may result in permanent neurologic damage)
Neonates, infants, small children: Midlateral aspect of thigh preferable
Older children and adults: Deep IM injection in upper outer quadrant of buttock
Because of high concentration of suspended matter, needle may be blocked if injection is not made at slow, steady rate
Contra Indications
A previous hypersensitivity reaction to any penicillin or to procaine is a contraindication.
Precautions
Penicillin should be used with caution in individuals with histories of significant allergies and/or asthma.
Care should be taken to avoid intravenous or intra-arterial administration, or injection into or near major peripheral nerves or blood vessels, since such injections may produce neurovascular damage
Lactation: Excreted into breast milk, caution advised
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Excreted into breast milk, caution advised
Interactions
Probenecid
Increases and prolongs serum penicillin levels.
Tetracycline
May antagonize the bactericidal effect of penicillin.
Side Effects
Side effects of Benzyl Penicillin + Procaine Penicillin :
As with other penicillins, untoward reactions of the sensitivity phenomena are likely to occur, particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with a history of allergy, asthma, hay fever, or urticaria.
The following have been reported with parenteral penicillin G:
General: Hypersensitivity reactions including the following: skin eruptions (maculopapular to exfoliative dermatitis), urticaria, laryngeal edema, fever, eosinophilia; other serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration); and anaphylaxis including shock and death.
Gastrointestinal: Pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment.
Mode of Action
Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other ?-lactamases.
Interferes with cell wall mucopeptide synthesis during active multiplication, resulting in bactericidal activity against susceptible microorganisms.
Note
Combipen 4 LAC 300k+100k units per Vial Injection generic name is Benzyl Penicillin + Procaine Penicillin. Combipen 4 LAC 300k+100k units per Vial Injection is manufactured by Acme Laboratories Ltd.Combipen 4 LAC is availble in all over Bangladesh.
Mes BD drug index information on Combipen 4 LAC Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.