Combigan Eye Drops

Brimonidine Tartrate 0.2% + Timolol Maleate 0.5% Eye prep

2mg+5mg

Eskayef Pharmaceuticals Ltd.

Pack size	5ml
Unite Price	712.00 BDT

Indications

Combigan Eye Drops is used for: Open-angle glaucoma, Ocular hypertension

Adult Dose

Adult: Ophth: Instill 1 drop 2 times/day approximately 12 hours apart.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity. Patients receiving MAO inhibitor therapy.

Precautions

Patients wearing soft contact lenses should wait for at least 15 min after instilling brimonidine tartrate before inserting soft contact lenses. Renal or hepatic impairment. CV disease. Use with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangitis obliterans. Pregnancy, lactation. Lactation: use caution

Pregnancy-Lactation

Pregnancy Category: C Lactation: use caution

Interactions

Brimonidine Tartrate: Possibility of an additive or potentiating effect with CNS depressants e.g. alcohol, barbiturates, opiates, sedatives or anaesthetics. Caution when used with ?-blockers (ophthalmic and systemic), antihypertensives or cardiac glycosides. TCAs can affect the metabolism and uptake of circulating amines. Timolol: Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive effects w/ other antihypertensives (e.g. hydralazine, methyldopa). Increased ?-adrenergic blockade (e.g. decreased heart rate) w/ quinidine. Rebound HTN due to abrupt withdrawal of clonidine. Hypotensive effect may be antagonised by NSAIDs (e.g. indomethacin, ibuprofen).

Side Effects

Side effects of Brimonidine Tartrate 0.2% + Timolol Maleate 0.5% Eye prep : 5-15% Allergic conjunctivitis, Conjunctival folliculosis, Conjunctival hyperemia, Eye pruritus, Ocular burning, Stinging 1-5% Asthenia, Blepharitis, Corneal erosion, Depression, Epiphora, Eye discharge, Eye dryness, Eye irritation, Eye pain, Eyelid edema, Eyelid erythema, Eyelid pruritus, Foreign body sensation, Headache, Hypertension, Oral dryness, Somnolence, Superficial punctate keratitis, Visual disturbance

Mode of Action

Brimonidine is an alpha 2-adrenoceptor agonist which works to reduce aqueous humor production and increase uveoscleral flow. Timolol is a non-selective beta-adrenergic receptor blocker. It does not have significant intrinsic sympathomimetic activity, direct myocardial depressant activity or local anaesth activity. Exact mechanism of ocular hypotensive effect is unclear, but it is thought to be related to reduction of aqueous humour formation. beta-blockade also causes lowering of BP.

Note

Combigan 2mg+5mg Eye Drops generic name is Brimonidine Tartrate 0.2% + Timolol Maleate 0.5% Eye prep. Combigan 2mg+5mg Eye Drops is manufactured by Eskayef Pharmaceuticals Ltd.Combigan is availble in all over Bangladesh. Mes BD drug index information on Combigan Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Brimonidine Tartrate 0.2% + Timolol Maleate 0.5% Eye prep :

Eye Drops

Brimodin Plus ^{200 mg + 500 mg/100 ml}

Incepta Pharmaceuticals Ltd.

Eye Drops

Combat ^0.2%+0.5%

General Pharmaceuticals Ltd.

Eye Drops

Combipres ^{0.2% + 0.5%}

Aristopharma Limited

Eye Drops

Timo-plus ^{200 mg + 500 mg/100 ml}

Reman Drug Laboratories Ltd.

Eye Drops

Brimopres ^{0.2% + 0.5%}

Popular Pharmaceuticals Ltd.