Cofno Syrup

Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride

10mg + 30mg + 1.25mg/5ml

Alco Pharma Limited

Pack size	100ml bot
Unite Price	70.21 BDT

Indications

Cofno Syrup is used for: Flu, Colds, Runny nose, Dry coughs, Non-productive cough, Nasal congestion

Adult Dose

Oral Cough and common cold Adult: 2 teaspoonful three times a day.

Child Dose

Children Over 12 years 2 teaspoonful three times a day 6-12 years 1 teaspoonful three times a day 2-6 years 1/2 teaspoonful three times a day or as directed by the physician

Renal Dose

Administration

Contra Indications

Patients at risk of developing resp failure. During an acute attack. Patients receiving MAOI or for 2 wk after discontinuing them. Persistent or chronic cough.

Precautions

3rd trimester of pregnancy; atopic childn; child <1 yr; sedated or debilitated patients; patients confined to supine position; history of asthma. Moderate to severe renal impairment; liver disease.

Pregnancy-Lactation

Interactions

Dextromethorphan: Tricyclic antidepressants (TCAs), antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol. Potentially Fatal: Memantine, moclobemide. Triprolidine + Pseudoephedrine: Increased BP with other sympathomimetic agents (e.g. decongestants, TCA, appetite suppressants). Reduced hypotensive effects of methyldopa, ?- and ?-adrenergic blockers. Increased side effects (e.g. somnolence, agitation) with atomoxetine. Potentially Fatal: Increased risk of hypertensive crisis with furazolidine, avoid concurrent use. Increased risk of hypertensive crisis with MAOIs; avoid concurrent use or within 2 wk after stopping MAOIs. Increased risk of psychosis with bromocriptine.

Side Effects

Side effects of Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride : Dizziness, GI disturbances.

Mode of Action

Triprolidine is a potent competitive histamine H1-receptor antagonist with mild sedating and antimuscarinic properties. Pseudoephedrine, an alpha- and beta-adrenergic receptor agonist, mediates vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. Dextromethorphan is a centrally acting cough suppressant which acts on the cough centre in the medulla.

Note

Cofno 10mg + 30mg + 1.25mg/5ml Syrup generic name is Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride. Cofno 10mg + 30mg + 1.25mg/5ml Syrup is manufactured by Alco Pharma LimitedCofno is availble in all over Bangladesh. Mes BD drug index information on Cofno Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Dextromethorphan + Pseudoephedrine Hydrochloride +Triprolidine Hydrochloride :

Syrup

Ankof ^{0.200gm+ 0.600gm + 0.025}

General Pharmaceuticals Ltd.

Syrup

Coprin ^{10 mg+30 mg+1.25 mg}

Doctor's Chemicals Works Ltd.

Syrup

Dexdin ^{10mg + 30mg + 1.25mg/5ml}

Somatec Pharmaceuticals Ltd.

Syrup

Dexitra

Novo Healthcare and Pharma Ltd.

Syrup

Dexodel Plus ^{10mg + 30mg + 1.25mg/5ml}

Delta Pharma Limited