Clorocef Powder For Suspension

Cefaclor
125 mg/5 ml
Ibn Sina Pharmaceutical Ind. Ltd.
Pack size 100ml bot
Unite Price 205.00 BDT

Indications

Clorocef Powder For Suspension is used for: Pneumonia, Meningitis, Peritonitis, Otitis media, Septicaemia, Biliary-tract infections, Urinary-tract infections, Skin and skin structure infections, Upper and lower respiratory tract infections, Pharyngitis, Tonsillitis

Adult Dose

Oral Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media Adult: As monohydrate: 250-500 mg every 8 hr. Max: 4 g daily.

Child Dose

Oral Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media Child: PO 20–40 mg/kg/day, max 1 g/day q12h 1-5 yr: 125 mg tid, >5 yr: 250 mg tid. Suspension & Paediatric Drops: 1 month - 1 year 2.5 ml t.i.d. 0.625 ml t.i.d 1 year - 5 year 5 ml t.i.d. 1.25 ml t.i.d over 5 years 10 ml t.i.d 2.5 ml t.i.d

Renal Dose

Renal Impairment CrCl: 10-50 mL/min: Half to full dose CrCl: <10 mL/min: Half dose

Administration

May be taken with or without food.

Contra Indications

Known hypersensitivity to cephalosporins.

Precautions

Severe renal impairment; history of allergy to penicillin; pregnancy, lactation. Lactation: enters breast milk; use with caution

Pregnancy-Lactation

Pregnancy No adequate and well-controlled studies in pregnant women Because animal reproduction studies are not always predictive of human response, cefaclor should be used during pregnancy only if necessary Lactation Effect on nursing infants is unknown; exercise caution when cefaclor is administered to a nursing woman Extended-release tablets No studies in lactating women performed; small amounts of cefaclor (?0.21 mcg/mL) detected in human milk following administration (single 500-mg dose of cefaclor extended-release tablets)

Interactions

May enhance the nephrotoxic effect of aminoglycosides. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. Concomitant use w/ warfarin may increase prothrombin time. Probenecid inhibits renal excretion of cefaclor.

Side Effects

Side effects of Cefaclor : 1-10% Diarrhea (3%), Increased transaminases (3%), Eosinophilia (2%), Moniliasis (2%), Vaginitis (2%), Rash (maculopapular, erythematous, or morbiliform) (1-2%) <1% Stevens-Johnson syndrome, Pseudomembranous colitis, Nausea, Vomiting, Anemia, Neutropenia, Jaundice Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.

Mode of Action

Cefaclor binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. It has bactericidal activity against gm-ve bacteria including E. coli, S. pneumoniae, N. gonorrhoea, P. mirabilis and H. influenzae.

Note

Clorocef 125 mg/5 ml Powder For Suspension generic name is Cefaclor. Clorocef 125 mg/5 ml Powder For Suspension is manufactured by Ibn Sina Pharmaceutical Ind. Ltd.Clorocef is availble in all over Bangladesh. Mes BD drug index information on Clorocef Powder For Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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