Clobac Powder for Suspension
Cefaclor
125mg/5ml
Opsonin Pharma Limited
| Pack size | 100ml bot |
|---|---|
| Unite Price | 180.00 BDT |
Indications
Clobac Powder for Suspension is used for:
Pneumonia, Meningitis, Peritonitis, Otitis media, Septicaemia, Biliary-tract infections, Urinary-tract infections, Skin and skin structure infections, Upper and lower respiratory tract infections, Pharyngitis, Tonsillitis
Adult Dose
Oral
Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media
Adult: As monohydrate: 250-500 mg every 8 hr. Max: 4 g daily.
Child Dose
Oral
Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media
Child: PO 20–40 mg/kg/day, max 1 g/day q12h
1-5 yr: 125 mg tid,
>5 yr: 250 mg tid.
Suspension & Paediatric Drops:
1 month - 1 year 2.5 ml t.i.d. 0.625 ml t.i.d
1 year - 5 year 5 ml t.i.d. 1.25 ml t.i.d
over 5 years 10 ml t.i.d 2.5 ml t.i.d
Renal Dose
Renal Impairment
CrCl: 10-50 mL/min: Half to full dose
CrCl: <10 mL/min: Half dose
Administration
May be taken with or without food.
Contra Indications
Known hypersensitivity to cephalosporins.
Precautions
Severe renal impairment; history of allergy to penicillin; pregnancy, lactation.
Lactation: enters breast milk; use with caution
Pregnancy-Lactation
Pregnancy
No adequate and well-controlled studies in pregnant women
Because animal reproduction studies are not always predictive of human response, cefaclor should be used during pregnancy only if necessary
Lactation
Effect on nursing infants is unknown; exercise caution when cefaclor is administered to a nursing woman
Extended-release tablets
No studies in lactating women performed; small amounts of cefaclor (?0.21 mcg/mL) detected in human milk following administration (single 500-mg dose of cefaclor extended-release tablets)
Interactions
May enhance the nephrotoxic effect of aminoglycosides. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. Concomitant use w/ warfarin may increase prothrombin time. Probenecid inhibits renal excretion of cefaclor.
Side Effects
Side effects of Cefaclor :
1-10%
Diarrhea (3%), Increased transaminases (3%), Eosinophilia (2%), Moniliasis (2%), Vaginitis (2%), Rash (maculopapular, erythematous, or morbiliform) (1-2%)
<1%
Stevens-Johnson syndrome, Pseudomembranous colitis, Nausea, Vomiting, Anemia, Neutropenia, Jaundice
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Mode of Action
Cefaclor binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. It has bactericidal activity against gm-ve bacteria including E. coli, S. pneumoniae, N. gonorrhoea, P. mirabilis and H. influenzae.
Note
Clobac 125mg/5ml Powder for Suspension generic name is Cefaclor. Clobac 125mg/5ml Powder for Suspension is manufactured by Opsonin Pharma LimitedClobac is availble in all over Bangladesh.
Mes BD drug index information on Clobac Powder for Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.