Clinex Plus Gel

Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical

1.2% + 0.025%

Aristopharma Limited

Pack size	15gm tube
Unite Price	150.00 BDT

Indications

Clinex Plus Gel is used for: Acne vulgaris

Adult Dose

Acne Vulgaris Topical Apply a pea-size amount of gel once daily preferably at bed time. Treatment should be continued for 12 weeks.

Child Dose

<12 years old: Safety and efficacy not established >12 years: Apply a pea-size amount of gel once daily preferably at bed time.

Renal Dose

Administration

At first wash the face or affected area gently with warm water or soap. When the skin is completely dried (about 30 minutes later) apply a pea-size amount of gel to your fingertip and spread it over your face.

Contra Indications

Contraindicated in patients with hypersensitivity to clindamycin or tretinoin or any of the ingredients of these medicine.

Precautions

Clindacin plus gel is not for oral, ophthalmic, or Intravaginal use. Avoid exposure to sunlight and sunlamps. Wear sunscreen daily. Lactation: excretion in milk unknown; use with caution

Pregnancy-Lactation

Pregnancy Category: C Lactation: excretion in milk unknown; use with caution

Interactions

Clindamycin: May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione). Tretinoin: Enhances percutaneous absorption of minoxidil. Increased risk of fatal thrombotic complications with antifibrinolytic. Increased tretinoin concentrations with azole antifungals. Enhances peeling action of sulphur, resorcinol, benzoyl peroxide, salicylic acid. Increased photosensitivity with photosensitising medications eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides. Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.

Side Effects

Side effects of Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical : >10% Erythema (21-35%), Scaling (13-19%), Itching (15-17%) 1-10% Dryness (6%), Irritation (5%), Exfoliation (5%), Erythema (4%), Pruritus (2%), Stinging (2%), Burning (2%), Sunburn (1%), Dermatitis (1%)

Mode of Action

Clindamycin: Antibacterial agent that binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing protein synthesis; reduces surface fatty acids on skin; exact mechanism of action in treating acne unknown Tretinoin: Exact mechanism unknown; appears to cohesiveness of follicular epithelial cells with decrease microcomedo formation; also increases turnover of follicular cells to cause extrusion of comedones

Note

Clinex Plus 1.2% + 0.025% Gel generic name is Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical. Clinex Plus 1.2% + 0.025% Gel is manufactured by Aristopharma LimitedClinex Plus is availble in all over Bangladesh. Mes BD drug index information on Clinex Plus Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Clindamycin Phosphate 1.2% + Tretinoin 0.025% Topical :

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