Celeco Capsule
Celecoxib
200mg
Medimet Pharmaceuticals Ltd.
| Pack size | 30's pack |
|---|---|
| Unite Price | 8.00 BDT |
Indications
Celeco Capsule is used for:
Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis, Dysmenorrhea, Acute pain, Familial adenomatous polyposis
Adult Dose
Oral
Osteoarthritis
Adult: 200 mg/day as a single dose or in 2 divided doses. May increase to 200 mg bid, if necessary.
Rheumatoid arthritis
Adult: 100-200 mg bid.
Dysmenorrhoea; Pain relief
Adult: Initially, 400 mg followed by 200 mg if necessary on the 1st day. Maintenance: 200 mg bid.
Ankylosing spondylitis
Adult: Initially, 200 mg/day as a single dose or in 2 divided doses. May increase to 400 mg/day after 6 wk.
Hepatic impairment: Moderate (Child-Pugh category B): Reduce dose by 50%. Severe (Child-Pugh category C or ?10 score): Contraindicated.
Child Dose
Juvenile idiopathic arthritis
Child: >2 yr >10 kg to <25 kg: 50 mg bid;
>25 kg: 100 mg bid.
Renal Dose
Administration
May be taken with or without food. Dose for OA/RA may be given w/ or w/o meals, but doses for FAP must be given w/ meals.
Contra Indications
Hypersensitivity including those in whom attacks of angioedema, rhinitis and urticaria have been precipitated by aspirin, NSAIDs or sulfonamides. Severe hepatic impairment; severe heart failure; inflammatory bowel disease; peptic ulcer; renal impairment (creatinine clearance <30 mL/min); pregnancy and lactation.
Precautions
History of GI bleeding; renal/hepatic insufficiency; asthma or allergic disorders; hypertension; monitor Hb or haematocrit levels for signs of anaemia. History of cerebrovascular disease or ischaemic heart disease (IHD).
Lactation: Drug enters breast milk; use caution
Pregnancy-Lactation
Pregnancy category: C; D at >30 weeks' gestation (may cause premature closure of ductus arteriosus)
Lactation: Drug enters breast milk; use caution
Interactions
May increase plasma level w/ CYP2C9 isoenzymes (e.g. fluconazole). May increase serum level of lithium. May reduce effect of antihypertensives and diuretics. May increase anticoagulant effect of warfarin.
Side Effects
Side effects of Celecoxib :
>10%
Headache (10-16%), Hypertension (13%)
1-10%
Fever (9%), Dyspepsia (8.8%), Upper respiratory tract infection (8.1%), Arthralgia (7%), Cough (7%), Vomiting (6%), Diarrhea (5.6%), Gastroesophageal reflux (5%), Sinusitis (5%), Abdominal pain (4.1%), Nausea (3.5%), Back pain (2.8%), Insomnia (2.3%), Pharyngitis (2.3%), Flatulence (2.2%), Rash (2.2%), Dizziness (2%), Peripheral edema (2%)
<1%
Anemia, Erythema multiforme, Exfoliative dermatitis, Hepatitis, Jaundice, Stevens-Johnson syndrome, Toxic epidermal necrolysis
Frequency Not Defined
Increased serum asparate aminotransferase concentration
Potentially Fatal: Serious skin reactions such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
Mode of Action
Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.
Note
Celeco 200mg Capsule generic name is Celecoxib. Celeco 200mg Capsule is manufactured by Medimet Pharmaceuticals Ltd.Celeco is availble in all over Bangladesh.
Mes BD drug index information on Celeco Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.