Indications
Ceftoren Tablet is used for:
Pharyngitis, Community-acquired pneumonia, Susceptible infections, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis
Adult Dose
Oral
Community-acquired pneumonia
Adult: 400 mg bid for 14 days.
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg bid for 10 days.
Pharyngitis ; Tonsillitis; Uncomplicated skin and skin structure infections
Adult: 200 mg bid for 10 days.
Child Dose
<12 years old: Safety & efficacy not established
>12 years old: As in adults
Renal Dose
Renal impairment:
CrCl (ml/min)
30-49 Maximum: 200 mg bid
<30 Maximum: 200 mg once daily
Administration
Should be taken with food.
Contra Indications
Hypersensitivity to Cefditoren, other cephalosporins; or milk proteins. Carnitine deficiency.
Precautions
Pregnancy and lactation. Patients with penicillin allergy. Avoid prolonged use as pivalate-containing compounds may cause carnitine deficiency over time; greater risk of carnitine deficiency in patients with renal impairment or decreased muscle mass. May decrease prothrombin activity especially in patients with renal or hepatic impairment, poor nutritional status, prolonged antibiotic treatment or patients previously stabilised on anticoagulant therapy. Long term use may result in development of drug-resistant bacteria, or superinfection including Clostridium difficile-associated diarrhoea and pseudomembranous colitis.
Lactation: excretion in milk unknown; use with caution
Pregnancy-Lactation
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Interactions
Reduced oral bioavailability when coadministered with antacids or H2-receptor antagonists. Probenecid may increase plasma concentration and prolong half-life of Cefditoren. May enhance anticoagulant effect of vitamin K antagonists (e.g. warfarin).
Side Effects
Side effects of Cefditoren :
>10%
Diarrhea (11-15%)
1-10%
Nausea (4-6%), Headache (2-3%), Abdominal pain (2%), Dyspepsia (1-2%), Vomiting (1%)
<1%
Bacterial/fungal superinfection, C. difficile colitis, Hypersensitivity, Increased bleeding time, Stevens-Johnson syndrome, Vaginal moniliasis
Potentially Fatal: Hypersensitivity, anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Mode of Action
Cefditoren is a third generation cephalosporin used for treatment of susceptible infections caused by gram-positive and gram-negative bacteria. It inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).
Note
Ceftoren 200mg Tablet generic name is Cefditoren. Ceftoren 200mg Tablet is manufactured by ACI LimitedCeftoren is availble in all over Bangladesh.
Mes BD drug index information on Ceftoren Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.