Indications
Cefopar IM/IV Injection is used for:
Respiratory Tract Infections, Peritonitis and Other Intra-abdominal Infections, Bacterial Septicemia, Infections of the Skin and Skin Structures, Pelvic Inflammatory Disease, Endometritis, and Other Infections of the Female Genital Tract, Urinary Tract Infections
Adult Dose
Parenteral
Susceptible infections
Adult: As sodium: 2-4 g daily in 2 divided doses, increased to 12 g daily in 2-4 divided doses for severe infections given as deep IM or IV infusion.
Hepatic impairment: Max for hepatic impairment or biliary obstruction: 4 g daily. W/ renal impairment: 1-2 g daily.
Child Dose
Renal Dose
Renal impairment: W/ hepatic impairment: 1-2 g daily.
Administration
Contra Indications
Hypersensitivity to cephalosporin.
Precautions
History of penicillin allergy; renal or hepatic impairment; pregnancy, lactation; cystic fibrosis.
Pregnancy-Lactation
Interactions
Disulfiram-like reaction with alcohol. Potentiates anticoagulants.
Potentially Fatal: Enhances nephrotoxicity by aminoglycosides and furosemide.
Side Effects
Side effects of Cefoperazone :
Skin rash, urticaria; eosinophilia, diarrhoea, nausea, vomiting; phloebitis; hypoprothrombinaemia; superinfection.
Potentially Fatal: Neuromuscular hypersensitivity; nephrotoxicity.
Mode of Action
Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Cefopar 1gm IM/IV Injection generic name is Cefoperazone. Cefopar 1gm IM/IV Injection is manufactured by Opsonin Pharma LimitedCefopar is availble in all over Bangladesh.
Mes BD drug index information on Cefopar IM/IV Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.