Indications
Cabita Tablet is used for:
Breast cancer, Colorectal cancer, Gastric cancer, Oesophageal cancer
Adult Dose
Oral
Breast cancer; Colorectal cancer
Adult: 1.25 g/m2 bid for 2 wk followed by a 1 wk rest period; therapy to be given in 3-wk cycles. Recommended treatment duration for colorectal cancer: 6 mth. May be used in combination with docetaxel at 75 mg/m2, given as a 1-hr IV infusion once every 3 wk for the treatment of breast cancer.
Gastric cancer
Adult: Used in combination with a platinum-based compound, 1 g/m2 bid for 14 days, followed by a 7-day rest period. 1st dose is given on the evening of day 1 and the last dose on the morning of day 15.
Child Dose
Renal Dose
Renal impairment:
CrCl (ml/min)
51-80 No adjustment needed.
30-50 Reduce dose to 950 mg/m2 bid when starting dose is 1.25 g/m2 bid. No dose adjustment is needed when starting dose is 1 g/m2.
<30 Avoid use.
Administration
Swallow with water within 30 min after a meal
Contra Indications
History of severe and unexpected reactions to fluoropyrimidine therapy; severe renal impairment; pregnancy, lactation. Hypersensitivity.
Precautions
Hepatic dysfunction, bone marrow suppression, poor nutritional status, warfarin therapy. Child, elderly, prior extensive pelvic radiation or alkylating therapy. Moderate renal impairment; CBC with differential; monitor hepatic and renal function. Discontinue use if intractable diarrhoea, stomatitis, bone marrow suppression or MI develops.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
Interactions
Antacids containing aluminum and magnesium, leucovorin, anticoagulants, phenytoin, allopurinol.
Side Effects
Side effects of Capecitabine :
10%
Diarrhea, Nausea, Anemia, Lymphopenia, Hand and foot syndrome, Edema, Fatigue, Fever, Headache, Pain, Paresthesia, Alopecia, Dermatitis, Abdominal pain, Anorexia, Appetite decreased, Constipation, Dyspepsia, Stomatitis, Vomiting, Neutropenia, Thrombocytopenia, Dyspnea, Bilirubin increased, Eye irritation
1-10%
Chest pain, Dermatitis, Pruritus, Rash, Dizziness, Headache, Weakness, Dehydration, Dry mouth, Dyspepsia, Taste disturbance, Back pain
Potentially Fatal: Cardiotoxicity, bone-marrow depression and hyperbilirubinaemia.
Mode of Action
Capecitabine is a prodrug that is converted to fluorouracil following oral administration, which in turn inhibits thymidylate synthetase, blocking the methylation of deoxyuridylic acid to thymidylic acid, interfering with DNA, and to a lesser degree, RNA synthesis.
Note
Cabita 500mg Tablet generic name is Capecitabine. Cabita 500mg Tablet is manufactured by Drug International Ltd.Cabita is availble in all over Bangladesh.
Mes BD drug index information on Cabita Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.