Budison F 160 Inhaler

Budesonide + Formoterol Fumarate

160mcg + 4.5mcg/Puff

Aristopharma Limited

Pack size	60 Puffs in Refill Pack
Unite Price	500.00 BDT

Indications

Budison F 160 Inhaler is used for: Asthma, COPD

Adult Dose

Asthma Maintenance and reliever therapy: Adults and adolescents (12 years and older) - As both maintenance and reliever therapy: Adults and adolescents (12 years and older): The recommended maintenance dose is 1 puff twice daily or 2 puffs once daily. For some patients a maintenance dose of 2 puffs twice daily may be appropriate (for 160/4.5 mcg/inhalation only). Patients should take 1 additional puff as needed in response to symptoms. If symptoms persist after a few minutes, the additional puff should be taken. Not more than 6 puffs should be taken on any single occasion. Convicap/cozycap: Maintenance dose: 100 Convicap twice daily. 200 Convicap twice daily. Reliever dose: 1 additional Convicap as needed in response to symptoms. If symptoms persist after a few minutes, an additional Convicap should be taken. COPD 200 Convicap: 2 Convicaps twice daily. 400 Convicap: 1 Convicap twice daily

Child Dose

<12 years: Safety and efficacy not established

Renal Dose

Administration

Contra Indications

Primary treatment of status asthmaticus or other acute episodes of asthma. Hypersensitivity to Budesonide, Formoterol or to Lactose.

Precautions

Treatment with Budesonide and Formoterol combination should not be initiated to treat a severe exacerbation or if patients have significantly worsening or acutely deteriorating asthma. May produce paradoxical bronchospasm which is life-threatening. Caution when used in patients with CV diseases, especially coronary insufficiency, cardiac arrhythmias and hypertension. Chronic use may further decrease bone mineral content when used in patients with advanced age, osteoporosis, poor nutrition, sedentary lifestyle or tobacco use. May reduce growth velocity when used in paediatric patients. Caution when used in patients with active or quiescent tuberculosis infection of the respiratory tract, untreated systemic fungal, bacterial, viral or parasitic infections, or ocular herpes simplex. Pregnancy and lactation. Lactation: No data; weigh risks of therapy against benefits, and either discontinue drug or do not nurse

Pregnancy-Lactation

Pregnancy In women with poorly or moderately controlled asthma, there is increased risk of several perinatal adverse outcomes such as preeclampsia in the mother and prematurity, low birth weight, and small for gestational age in neonate; pregnant women with asthma should be closely monitored and medication adjusted as necessary to maintain optimal asthma control There are no well-controlled human studies that have investigated the effects of therapy during labor and delivery; because of potential for beta-agonist interference with uterine contractility, use of therapy during labor should be restricted to those patients in whom the benefits clearly outweigh risk Lactation There are no available data on the breastfed child or on milk production; budesonide, like other inhaled corticosteroids, is present in human milk; there are no available data on the presence of formoterol fumarate in human milk; formoterol fumarate is present in rat milk; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on the breastfed infant from therapy or from underlying maternal condition

Interactions

Concomitant admin with CYP3A4 inhibitor e.g. itraconazole, clarithromycin, erythromycin may inhibit the metabolism of budesonide. Concurrent use with nonpotassium-sparing diuretics may lead to ECG changes and/or hypokalaemia.

Side Effects

Side effects of Budesonide + Formoterol Fumarate : >10% Upper respiratory tract infection (URTI) (8-11%), Headache (7-11%), Nasopharyngitis (7-11%) 1-10% Pharyngolaryngeal pain (6-9%), Stomach discomfort (1-7%), Sinusitis (5-6%), Oral candidiasis (1-6%), Bronchitis (5%), Viral URTI (4%), Backache (2-3%), Influenza (2-3%), Nasal congestion (2-3%), Vomiting (1- 3%)

Mode of Action

Budesonide is a corticosteroid that has mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein syntheis, decreasing the migration of polymorphonuclear leucocytes/fibroblasts and reversing capillary permeability. Formoterol fumarate is a selective beta2-adrenergic agonist. It causes bronchodilation by catalysing the conversion of adenosine triphosphate to cyclic-3', 5'-adenosine monophosphate (cyclic AMP) resulting in bronchial smooth muscle relaxation.

Note

Budison F 160 160mcg + 4.5mcg/Puff Inhaler generic name is Budesonide + Formoterol Fumarate. Budison F 160 160mcg + 4.5mcg/Puff Inhaler is manufactured by Aristopharma LimitedBudison F 160 is availble in all over Bangladesh. Mes BD drug index information on Budison F 160 Inhaler is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Budesonide + Formoterol Fumarate :

Inhalation Capsule

Budemet 100 ConviCap ^{100/6 µg}

Incepta Pharmaceuticals Ltd.

Inhalation Capsule

Budemet 200 Convicap ^{200/6 µg}

Incepta Pharmaceuticals Ltd.

Inhalation Capsule

Budemet 400 Convicap ^{400/12 µg}

Incepta Pharmaceuticals Ltd.

Inhaler

Budison F 80 ^{80mcg + 4.5mcg/Puff}

Aristopharma Limited

Cozycap

Bufocort 200 ^{200mcg + 6mcg}

Square Pharmaceuticals Ltd.