Bpclox Syrup

Cloxacillin
125 mg/5 ml
Bristol Pharma Ltd.
Pack size 100 ml bot
Unite Price 44.00 BDT

Indications

Bpclox Syrup is used for: Staphylococcal infections resistant to benzylpenicillin

Adult Dose

Oral Adult: 250-500 mg 4 times/day. Parenteral Adult: 1-2 g 6 hrly. For more severe infections (e.g. meningitis, endocarditis), 2 g 4 hrly.

Child Dose

Oral Child: 50-100 mg/kg in divided doses every 6 hr.

Renal Dose

Administration

Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals. Reconstitution: IM: The contents of each vial should be dissolved in 1.5 mL of water for inj. IV: 500 mg to be dissolved in 10-20 mL of water for inj, added to suitable IV fluids if given for i

Contra Indications

Hypersensitivity to cloxacillin and other penicillins.

Precautions

Patient w/ allergies esp β-lactam allergy, asthma, history of seizure disorder. Renal impairment. Pregnancy and lactation. Monitoring Parameters Observe for signs and symptoms of anaphylaxis during 1st dose. Monitor CBC w/ differential (prior to initiating therapy and wkly thereafter), periodic BUN, creatinine, hepatic function.

Pregnancy-Lactation

Interactions

May diminish the effect of BCG and typhoid vaccine. May increase risk of methotrexate toxicity. May diminish the therapeutic effect of Na picosulfate. May decrease serum concentrations of mycophenolate. May prolong bleeding time w/ anticoagulants. Increased serum concentrations w/ probenecid. Tetracycline may antagonise the bactericidal effect of cloxacillin.

Side Effects

Side effects of Cloxacillin : Hypotension, confusion, fever, lethargy, seizure, pruritus, rash, urticaria, abdominal pain, black or hairy tongue, diarrhoea, flatulence, nausea, oral candidiasis, pseudomembranous colitis, stomatitis, vomiting, agranulocytosis, bone marrow depression, eosinophilia, granulocytopenia, haemolytic anaemia, leucopenia, neutropenia, thrombocytopenia, increased alkaline phosphatase, ALT and AST, hepatotoxicity, thrombophlebitis, arthralgia, myalgia, myoclonus, hematuria, interstitial nephritis, proteinuria, renal insufficiency, renal tubular damage, bronchospasm, laryngeal oedema, laryngospasm, sneezing, wheezing, angioedema, allergic reaction, serum sickness-like reaction. Potentially Fatal: Anaphylaxis.

Mode of Action

Cloxacillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Note

Bpclox 125 mg/5 ml Syrup generic name is Cloxacillin. Bpclox 125 mg/5 ml Syrup is manufactured by Bristol Pharma Ltd.Bpclox is availble in all over Bangladesh. Mes BD drug index information on Bpclox Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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