Avloclav Powder For Suspension
Amoxicillin + Clavulanic Acid (Clavulanate)
(125mg+31.25mg)/5ml
ACI Limited
| Pack size | 100ml |
|---|---|
| Unite Price | 220.00 BDT |
Indications
Avloclav Powder For Suspension is used for:
Bacterial infections, Acute otitis media, Acute bacterial sinusitis, Endocarditis, Dental abscess, Community-acquired pneumonia, Acute uncomplicated UTI, Uncomplicated gonorrhea, Severe or recurrent resp tract infections
Adult Dose
Adults: PO: One 375 mg tablet 3 times a day. In severe infection one 625mg tablet 3 times a day or one 1gm tablet two times a day.
IV Injection: 1.2 g every 6-8 hours
Hepatic impairment: Dose with caution; monitor hepatic function regularly
Child Dose
Children: 125/31.25-, 250/62.5-mg/5-mL susp: 20–40 mg amoxicillin component/kg/day (max 1,500 mg/day) q8h
200/28.5-, 400/57-mg/5-mL susp: 25-45 mg amoxicillin component/kg/day (max 1,750 mg/day) q12h
Children of 6-12 years: 2 teaspoonful Powder for Suspension every 8 hours.
Children of 1-6 years: 1 teaspoonful Powder for Suspension every 8 hours.
Children below 1 year: 25 mg/kg/day in divided doses every 8 hours.
Children over 12 years: IV Injection: 1.2 g every 6-8 hours,
Children up to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants);
Child 3 months-12 years, 30 mg/kg every 6-8 hours.
Renal Dose
Renal impairment
CrCl <30 mL/min: Do not use 875/125 mg tablet or extended-release tablets
CrCl 10-30 mL/min: 250-500/125 mg PO q12hr
CrCl <10 mL/min: 250-500/125 mg PO q24hr
Hemodialysis: 250-500/125 mg PO q24hr; administer additional dose both during and at end of dialysis
Administration
Take with meals to avoid GI upset
Take suspension at start of meal to enhance absorption
Reconstitution: Powd for inj: Dissolve amoxicillin/clavulanic acid 500/100 mg in 10 mL solvent and 1,000/200 mg in 20 mL solvent. May further dilute to infusion soln containing either water for inj or NaCl 0.9%.
Contra Indications
Penicillin allergy.
Precautions
History of allergy especially to cephalosporins, infectious mononucleosis, severe renal impairment.
Lactation: Drug excreted in breast milk; use caution
Pregnancy-Lactation
Pregnancy category: B
Lactation: Drug excreted in breast milk; use caution
Interactions
Allopurinol may reduce renal tubular secretion of amoxicillin thus increasing the serum levels of amoxicillin. Concurrent use may reduce the efficacy of oral contraceptives.
Side Effects
Side effects of Amoxicillin + Clavulanic Acid (Clavulanate) :
>10%
Diarrhea (3-34%; varies upon dose and regimen)
1-10%
Diaper rash (3.5%), Mycosis (3.3%), Nausea (2-3%), Rash (1-3%), Vomiting (1-2.2%), Loose stool (1.6%), Candidiasis (1.4%), Vaginitis (1%)
<1%
Hypersensitivity reactions, Anaphylaxis, Anemia, Thrombocytopenia, Leukopenia, Agranulocytosis, Hepatoxicity, AST/ALT elevation, Pseudomembranous colitis, Serum sickness, Abdominal discomfort, Cholestatic jaundice, Flatulence
Potentially Fatal: Anaphylactic reaction with CV collapse esp with parenteral use.
Mode of Action
Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate amoxicillin by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with amoxicillin extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.
Note
Avloclav (125mg+31.25mg)/5ml Powder For Suspension generic name is Amoxicillin + Clavulanic Acid (Clavulanate). Avloclav (125mg+31.25mg)/5ml Powder For Suspension is manufactured by ACI LimitedAvloclav is availble in all over Bangladesh.
Mes BD drug index information on Avloclav Powder For Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.