Avifix Tablet
Nelfinavir
250mg
Beximco Pharmaceuticals Ltd.
| Pack size | 10's pack |
|---|---|
| Unite Price | 45.00 BDT |
Indications
Avifix Tablet is used for:
HIV infection
Adult Dose
Oral
HIV infection
Adult: Combined with other antiretrovirals: 1.25 g bid or 0.75 g tid.
Hepatic Impairment
Mild impairment (Child-Pugh class A): Dose adjustment not necessary
Severe impairment (Child-Pugh Class B or C): Not recommended
Child Dose
Oral
HIV infection
Child: Combined with other antiretrovirals:
2-13 yr: 45-55 mg/kg bid or 25-35 mg/kg tid. Max: 0.75 g tid.
Max Dosage: Child: 0.75 g tid.
Renal Dose
Renal Impairment
Dose adjustment not necessary
Administration
Should be taken with food.
Contra Indications
Hypersensitivity; lactation.
Precautions
Pregnancy. Hepatic and renal impairment; haemophilia A or B; diabetes. Monitor for signs of lipodystrophy.
Lactation: HIV+ women are advised not to breastfeed
Pregnancy-Lactation
Pregnancy Category: B
Lactation: HIV+ women are advised not to breastfeed
Interactions
Reduced levels/effects with antacids, phenobarbital, carbamazepine, aminoglutethimide, phenytoin, rifampicin, nafcillin, nevirapine, omeprazole, nevirapine. Increased serum levels/effects with azole antifungal agents, cimetidine, efavirenz. Increased serum levels/effects of azithromycin, calcium channel blockers, clarithromycin, corticosteroids (e.g. fluticasone), mirtazapine, nateglinide, nefazodone, ciclosporin, sirolimus, tacrolimus, venlafaxine, eplerinone, fentanyl, atorvastatin, phosphodiesterase-5 (PDE-5) inhibitors, rifabutin, trazodone, TCAs. Reduced serum levels/effects of hormonal contraceptives, methadone, theophylline derivatives.
Potentially Fatal: Increased serum levels/toxicity of amiodarone, cisapride, pimozide, midazolam, triazolam, ergot alkaloids, lovastatin, simvastatin, quinidine.
Side Effects
Side effects of Nelfinavir :
>10%
Diarrhea (14-20%)
1-10%
Nausea (3-7%), Flatulence (1-5%), Abdominal pain (1%), Anemia (1%), Allergic reaction (1%), Impaired concentration (1%), Lipodystrophy (1%), Metabolic acidosis (1%), Rash (1-3%), Leukopenia (1%), Thrombocytopenia (1%), Weakness (1%)
<1%
QTc prolongation, Torsades de pointes, Diabetes mellitus, new onset and exacerbation, Hyperglycemia
Mode of Action
Nelfinavir is a selective, competitive, reversible HIV protease inhibitor. It inhibits HIV-1 protease preventing the cleavage of the gag-pol polyprotein resulting in the production of noninfectious virus.
Note
Avifix 250mg Tablet generic name is Nelfinavir. Avifix 250mg Tablet is manufactured by Beximco Pharmaceuticals Ltd.Avifix is availble in all over Bangladesh.
Mes BD drug index information on Avifix Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.