Apagrel Tablet
Prasugrel
10mg
Healthcare Pharmaceuticals Ltd.
| Pack size | 30's pack |
|---|---|
| Unite Price | 20.00 BDT |
Indications
Apagrel Tablet is used for:
Acute coronary syndromes, thrombotic cardiovascular (CV) events, stent thrombosis, unstable angina (UA), non-ST-elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI), Stroke
Adult Dose
Oral
Acute coronary syndrome
Adult: 60 mg as loading dose, followed by 10 mg once daily for up to 12 mth, given in combination w/ aspirin.
Elderly: >75 yr Maintenance: 5 mg once daily.
Patient w/ low body wt (<60 kg): 5 mg once daily as maintenance dose.
Hepatic impairment: Severe (Child-Pugh class C): Contraindicated.
Child Dose
Renal Dose
Renal impairment
Dose adjustment not necessary
Administration
May be taken with or without food.
Contra Indications
Active pathological bleeding such as peptic ulcer or intracranial hamorrhage. Patient with a history of prior transient ischemic attack or stroke
Precautions
Patient w/ propensity to bleed, low body wt (<60 kg). Patient who will undergo CABG and other surgical procedure; coronary angiography in UA/NSTEMI patients. Elderly (>75 yr). Pregnancy and lactation. Monitoring Parameters Monitor Hb and haematocrit periodically; may consider platelet function testing.
Pregnancy-Lactation
Pregnancy
There are no data with prasugrel use in pregnant women to inform a drug-associated risk
Due to the mechanism of action, and the associated identified risk of bleeding, consider the benefits and possible risks to the fetus when prescribing prasugrel to a pregnant woman
Lactation
There is no information regarding the presence of prasugrel in human milk, the effects on the breastfed infant, or the effects on milk production
Metabolites of prasugrel were found in rat milk
Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for prasugrel and any potential adverse effects on the breastfed child from prasugrel or from the underlying maternal condition
Interactions
Increased risk of bleeding w/ oral anticoagulants (e.g. warfain), clopidogrel, NSAIDs and fibrinolytics.
Side Effects
Side effects of Prasugrel :
1-10%
Bleeding, Anemia, Atrial fibrillation, Back pain, Bradycardia, Dizziness, Dyspnea, Headache, Hypertension, Nausea
<1%
Thrombotic thrombocytopenic purpura, Abnormal hepatic function, Angioedema, Hematoma, Hemolysis, Hemorrhage, Abnormal liver function
Mode of Action
Prasugrel is a prodrug that inhibits platelet activation and aggregation. The active metabolite irreversibly blocks the P2Y12 component of adenosine diphosphate (ADP) receptors on the platelet, which prevents activation of the GPIIb/IIIa receptor complex, thereby reducing platelet activation and aggregation.
Note
Apagrel 10mg Tablet generic name is Prasugrel. Apagrel 10mg Tablet is manufactured by Healthcare Pharmaceuticals Ltd.Apagrel is availble in all over Bangladesh.
Mes BD drug index information on Apagrel Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.