Amocal BZ 5/10 Capsule
Amlodipine + Benazepril Hydrochloride
5 mg + 10 mg
Opsonin Pharma Limited
| Pack size | 30's pack |
|---|---|
| Unite Price | 6.02 BDT |
Indications
Amocal BZ 5/10 Capsule is used for:
Hypertension
Adult Dose
Oral
Hypertension
Adult: Amlodipine component: 2.5-10 mg once daily; benazepril component: 10-40 mg once daily. Titrate dose gradually according to response.
Elderly: Initiate with 2.5 mg Amlodipine component once daily.
Hepatic impairment: Initiate with 2.5 mg Amlodipine component once daily. Titrate combination slowly in severe hepatic impairment.
Child Dose
Safety and efficacy in paediatric patients have not been established.
Renal Dose
Renal impairment: Decrease dose if CrCl <30 mL/min, severe liver impairment, or coadministered with diuretic
Administration
May be taken with or without food.
Contra Indications
Patients with history of angioedema; pregnancy, lactation.
Precautions
Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death. Caution in elderly, renal or hepatic impairment, congestive heart failure, severe aortic stenosis, unilateral or bilateral renal artery stenosis, use during surgery or anaesthesia. Amlodipine+Benazepril can cause symptomatic hypotension, especially in patients with salt/volume depletion. ACE inhibitors (ACEi) have been associated with cholestatic jaundice and fulminant hepatic necrosis; discontinue treatment if patient develops jaundice/marked elevation of liver enzymes.
Monitor renal function and serum potassium periodically. Angioedema of the face, extremities, lips, tongue, glottis, larynx and intestinal angioedema have been reported in ACEi-treated patients. As with all ACEi, may cause persistent dry cough.
Lactation: Minimal amounts of benazepril enters milk, but excretion of amlodipine is not known; not recommended
Pregnancy-Lactation
Pregnancy category: D
Lactation: Minimal amounts of benazepril enters milk, but excretion of amlodipine is not known; not recommended
Interactions
Additive effect when used with catecholamine depleting drugs; monitor for hypotension and/or marked bradycardia. If used with clonidine, clonidine withdrawal should occur a few days after withdrawal of the beta-blocker to prevent rebound hypertension; if replacing clonidine by beta-blocker, beta-blocker should be introduced only after clonidine administration has stopped for several days. Concurrent use with prostaglandin synthase inhibiting drugs (e.g. indomethacin) may reduce the hypotensive effects of beta-blockers.
Side Effects
Side effects of Amlodipine + Benazepril Hydrochloride :
>10%
Amlodipine
Peripheral edema (2-15%), Pulmonary edema (7-15%)
1-10%
Amlodipine
Abdominal pain (1.6%), Dizziness (1.1-3.4%), Dyspepsia (1-2%), Fatigue (4.5%), Flushing (0.7-2.6%), Headache (7.3%), Male sexual dysfunction (1-2%), Muscle cramps (1-2%), Nausea (2.9%), Palpitation (0.7-4.5%), Rash (1-2%), Somnolence (1-2%), Weakness (1-2%)
Benazepril
ARF if renal artery stenosis
Cough (1-10%), Dizziness (4%), Fatigue (2%), Headache (6%), Nausea (1%), Postural dizziness (2%), Serum creatinine increased (2%), Somnolence (2%)
Potentially Fatal: Analphylactoid reactions, angioedema, Stevens-Johnson syndrome.
Mode of Action
Amlodipine is a dihydropyridine calcium antagonist. It lowers BP by relaxing the coronary vascular smooth muscles and producing coronary vasodilation; through inhibition of transmembrane Ca ion influx into vascular smooth muscle and cardiac muscle. It is also a peripheral vascular vasodilator. Benazepril and its active metabolite benazeprilat inhibit ACE, which results in decreased plasma angiotensin II and thus leading to decreased aldosterone secretion.
Note
Amocal BZ 5/10 5 mg + 10 mg Capsule generic name is Amlodipine + Benazepril Hydrochloride. Amocal BZ 5/10 5 mg + 10 mg Capsule is manufactured by Opsonin Pharma LimitedAmocal BZ 5/10 is availble in all over Bangladesh.
Mes BD drug index information on Amocal BZ 5/10 Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.