Ametrol VT Vaginal Tablet
Metronidazole + Miconazole Nitrate Vag prep
100 mg+100 mg
Ambee Pharmaceuticals Ltd.
| Pack size | 10's pack |
|---|---|
| Unite Price | 11.04 BDT |
Indications
Ametrol VT Vaginal Tablet is used for:
Vaginal candidiasis, Bacterial and trichomonal vaginitis
Adult Dose
Adult: Vag candidiasis: 100 mg every night for 7-14 days.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity; hepatic impairment (oral gel). Porphyria.
Precautions
For external use only; discontinue if sensitization or irritation occurs. Pregnancy and lactation
Pregnancy-Lactation
Interactions
Metronidazole: Disulfiram-like reaction w/ alcohol. Increased oral anticoagulant effect, blood levels of phenytoin, lithium toxicity, plasma conc of astemizole & terfenadine; blood conc of carbamazepine. Decreased blood levels w/ phenobarb. Risk of CNS-related effects (eg psychotic reactions) w/ disulfiram. Increased blood levels & neurologic effects w/ cimetidine. May increase blood levels & toxicity of fluorouracil; toxicity of cyclosporine. Increased cardiotoxicity w/ amiodarone. Interference w/ blood levels of liver enzymes, glucose (hexokinase method), theophylline & procainamide. Decreased levels w/ phenytoin.
Miconazole: Increased risk of bleeding w/ acenocoumarol, anisindione, dicumarol, phenindione, phenprocoumon, warfarin; plasma conc & exposure to oxybutinin. May increase risk of phenytoin, phosphenytoin, cyclosporine, trimetrexate toxicity & cardiotoxicity w/ pimozide. May inhibit metabolism of astemizole, cisapride & terfenadine. Reduced carbamazepine metabolism. Increased or prolonged effects of opioid (fentanyl). May cause hypoglycemia w/ glimepiride. Reduced clearance & increased plasma conc of oxycodone. May increase bioavailability of tolterodine (in patients w/ deficient CYP2D6 activity).
Side Effects
Side effects of Metronidazole + Miconazole Nitrate Vag prep :
Nausea, vomiting, febrile reactions, rash, drowsiness, diarrhoea, anorexia and flushing, hepatitis. Local irritation and sensitisation, contact dermatitis.
Mode of Action
Metronidazole is converted to reduction products that interact w/ DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes.
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.
Note
Ametrol VT 100 mg+100 mg Vaginal Tablet generic name is Metronidazole + Miconazole Nitrate Vag prep. Ametrol VT 100 mg+100 mg Vaginal Tablet is manufactured by Ambee Pharmaceuticals Ltd.Ametrol VT is availble in all over Bangladesh.
Mes BD drug index information on Ametrol VT Vaginal Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.