Aerophin Nebuliser Solution
Racepinephrine
11.25 mg/0.5 ml
Incepta Pharmaceuticals Ltd.
| Pack size | 10's Pack |
|---|---|
| Unite Price | 25.00 BDT |
Indications
Aerophin Nebuliser Solution is used for:
Asthma, Stridor, Wheezing
Adult Dose
Adults: Hand-held Bulb Nebulizer: 1 to 3 inhalations not more often than every 3 hours
Jet Nebulizer: Administer for fifteen minutes every 3 to 4 hours
Do not use more than 12 inhalations in 24 hours.
Child Dose
Children 4 years of age and over: Hand-held Bulb Nebulizer: 1 to 3 inhalations not more often than every 3 hours
Jet Nebulizer: Administer for fifteen minutes every 3 to 4 hours
Do not use more than 12 inhalations in 24 hours.
The use of this product by children should be supervised by an adult.
Renal Dose
Administration
The ingredient is used in an aqueous solution at a concentration equivalent to 1 percent epinephrine
For use in a Hand-held Bulb Nebulizer: Racepinephrine inhalation solution does not require dilution
For use in a Jet Nebulizer: One 0.5 mL vial should be diluted to a volume of 3 to 5 mL with sterile 0.9% sodium chloride solution
Contra Indications
Racepinephrine is contraindicated in patients with a history of hypersensitivity to it or adrenergic amines. Racepinephrine should not be used in patients with heart disease, high blood pressure,thyroid disease, diabetes, or difficulty in urination due to enlargement of the prostate gland unless directed by a doctor. Racepinephrine is contraindicated in patients taking monoamine oxidase inhibitor (MAO inhibitors), or for 2 weeks after stopping the MAOI drug.
Precautions
Racepinephrine should be used cautiously inpatients with: cardiac disease (angina, tachycardia, MI); hypertension; hyperthyroidism; diabetes; cerebral arteriosclerosis. Excessive use may lead to tolerance and paradoxical bronchospasm. Besides, geriatric patients are susceptible to adverse reactions.
Besides, it is advised not to use Racepinephrine if symptoms are not relieved within 20 minutes or become worse.
Racepinephrine solution should not be used if it is brown in color or cloudy, pinkish or if it contains a precipitate.
Pregnancy-Lactation
Racemic epinephrine is a 1:1 mixture of the Dextrorotatory (D) and Levorotatory (L) isomers of epinephrine. Epinephrine has been assigned to pregnancy category C by the FDA. Epinephrine is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk. Epinephrine is excreted into human milk. Due to the potential for serious adverse effects in nursing infants, a decision should be made to discontinue nursing or discontinue the drug.
Interactions
Side Effects
Side effects of Racepinephrine :
Cardiovascular
Cardiovascular side effects have included elevations of heart rate and blood pressure. In smaller doses, racepinephrine has caused peripheral coronary arterial vasodilation, but in larger doses, racepinephrine has caused diffuse vasoconstriction. This has caused increased peripheral vascular resistance, which was important in patients with coronary artery disease (worsened myocardial ischemia/angina) or hypertension (risk of emergent hypertension/stroke).
Arrhythmias, including fatal ventricular fibrillation, have been reported in patients with underlying cardiac disease. Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease. Angina may occur in patients with coronary artery disease.
Gastrointestinal
Gastrointestinal side effects have included nausea and vomiting.
Nervous system
Nervous system side effects have included fear, agitation, anxiety, tenseness, restlessness, headache, tremor, dizziness, lightheadedness, nervousness, sleeplessness, excitability, weakness, and increased parkinsonian tremors.
Psychiatric
Psychiatric side effects have included agitation, disorientation, impaired memory, aggressive or assautive behavior, hallucinations, and psychosis.
Mode of Action
Racemic epinephrine works by stimulation of the alpha-adrenergic receptors in the airway with resultant tightening of the mucosa (mucosal vasoconstriction) and decreased fluid in the airway (subglottic edema) and by stimulation of the beta-adrenergic receptors causing relaxation of the bronchial smooth muscle.
Note
Aerophin 11.25 mg/0.5 ml Nebuliser Solution generic name is Racepinephrine. Aerophin 11.25 mg/0.5 ml Nebuliser Solution is manufactured by Incepta Pharmaceuticals Ltd.Aerophin is availble in all over Bangladesh.
Mes BD drug index information on Aerophin Nebuliser Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.