Adribin 50 Injection

Doxorubicin Hydrochloride
50mg/vial
Healthcare Pharmaceuticals Ltd.
Pack size
Unite Price 1100.00 BDT

Indications

Adribin 50 Injection is used for: AIDS-related Kaposi's sarcoma, Ovarian carcinoma, Metastatic breast carcinoma, bladder carcinoma

Adult Dose

Intravenous As Doxorubicin liposomal Kaposi's Sarcoma Indicated for AIDS-related Kaposi’s sarcoma in patients after failure of prior systemic chemotherapy or intolerance to such therapy 20 mg/m² IV q3Weeks Ovarian Cancer Indicated for ovarian cancer in patients whose disease has progressed or recurred after platinum-based chemotherapy 50 mg/m² IV q4Weeks x 4 courses minimum Multiple Myeloma Indicated in combination with bortezomib for multiple myeloma in patients who have not previously received bortezomib and have received at least 1 prior therapy 30 mg/m² IV on day 4 following bortezomib 1.3 mg/m² on days 1, 4, 8 & 11 q3Weeks Metastatic breast cancer Adult: 60-75 mg/m2 BSA once every 3 wk in combination with cyclophosphamide given as an infusion over 1 hr diluted in 0.9% sodium chloride or 5% glucose. Irrigation Local malignant neoplasms in the bladder Adult: 50 ml of a 1 mg/ml solution instilled into the bladder for 1 hr once a mth. Hepatic Impairment Serum bilirubin <1.2 mg/dL: Dose adjustment not necessary Serum bilirubin 1.2-3 mg/dL [20.5-51.3 micromoles/L]: Give 50% dose Serum bilirubin: 3.1-5 mg/dL [53-85.5 micromoles/L]: Give 25% dose Severe hepatic impairment: Contraindicated

Child Dose

Safety and efficacy not established

Renal Dose

Renal Impairment Dose adjustment not necessary

Administration

Contra Indications

Cardiac disease, neonates, pregnancy and lactation, prior irradiation to mediastinum. IM/SC admin. Severe myelosuppression due to previous treatment with antitumour agents or radiotherapy.

Precautions

Elderly, children, hepatic impairment. Monitor blood counts and ECG. Lactation: Enters breast milk/not recommended

Pregnancy-Lactation

Pregnancy Category: D Lactation: Enters breast milk/not recommended

Interactions

Doxorubicin interacts with a number of other drugs e.g. antibiotics (aminoglycosides), steroids, aminophylline and propranolol. Potentially Fatal: Cholestasis induced by mercaptopurine may be potentiated by concurrent administration of the drug. Toxicity may be increased if streptozocin is given concurrently.

Side Effects

Side effects of Doxorubicin Hydrochloride : >10% Kaposi's Sarcoma Anemia (>50%), Thrombocytopenia (>50%), Neutropenia (10-50%), Anemia (18.2%), Nausea (17%) Ovarian cancer >25% Hand-foot syndrome (50%), Nausea (46%), Stomatitis (41%), Asthenia (40.2%), Vomiting (32.6%), Rash (28%), Constipation (>25%), Abdominal pain (>25%) Ovarian cancer 10-25% Fever (21.3%), Anorexia (20%), Diarrhea (20%), Peripheral edema, Dyspepsia, Pharyngitis, Dyspnea, Alopecia 1-10% Kaposi's Sarcoma 5-10% Asthenia (9.9%), Fever (9.1%), Diarrhea (7.8%), Vomiting (7.8%), Stomatitis (6.8%), Rash (1-5%), Alopecia (1-5%), Increased alkaline phosphatase Kaposi's Sarcoma 1-5% Hand-foot syndrome (3.4%), Hypotension, Tachycardia, Dyspnea, Hemolysis, Rash Ovarian cancer (selected) Neutropenia (13.3%), Anemia (0.4-5.4%), Thrombocytopenia (1.3%) <1% Abscess, Acute myeloid leukemia, Cardiomegaly, Cardiomyopathy, Erythema nodosum, Hyperkalemia, Hyperuricemia, Ketosis Potentially Fatal: Bone marrow suppression, cardiotoxicity.

Mode of Action

Doxorubicin is a cytotoxic anthracycline antibiotic. The cytotoxic action results from its binding to DNA and inhibition of nucleic acid synthesis. Doxorubicin has been shown to produce regression in a variety of disseminated malignancies.

Note

Adribin 50 50mg/vial Injection generic name is Doxorubicin Hydrochloride. Adribin 50 50mg/vial Injection is manufactured by Healthcare Pharmaceuticals Ltd.Adribin 50 is availble in all over Bangladesh. Mes BD drug index information on Adribin 50 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Doxorubicin Hydrochloride :

Injection
Xorubin 50mg/vial
Beacon Pharmaceuticals Ltd.
Injection
Xorubin 10mg/vial
Beacon Pharmaceuticals Ltd.
Injection
Doxorubicin Hexal 10mg/100ml
Novartis (Bangladesh) Ltd.
Injection
Doxorubicin Hexal 100mg/50ml
Novartis (Bangladesh) Ltd.
Injection
Doxorubicin Hexal 50mg/25ml
Novartis (Bangladesh) Ltd.