Indications
Adinir Capsule is used for:
Community-acquired pneumonia, Susceptible infections, Sinusitis, Otitis media, Sore throat, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis, Acute Maxillary Sinusitis
Adult Dose
Community-Acquired Pneumonia, Skin/Skin Structure Infections
300 mg PO q12hr for 10 days
Respiratory Tract Infections, Acute Maxillary Sinusitis
300 mg PO q12hr or 600 mg PO q24hr for 10 days
Hepatic impairment
No dosage adjustment necessary
Child Dose
<6 months: Safety and efficacy not established
6 months-12 years: 7 mg/kg PO q12hr for 5-10 days or 14 mg/kg PO q24hr for 10 days
>12 years or >43 kg: 300 mg PO q12hr or 600 mg PO q24hr for 10 days
Renal Dose
Renal impairment:
CrCl (ml/min)
<30 300 mg once daily.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity.
Precautions
Penicillin-sensitive patients; superinfection; seizure; pseudomembranous colitis; pregnancy, lactation; renal or hepatic insufficiency.
Lactation: Unknown whether drug is excreted in milk
Pregnancy-Lactation
Pregnancy category: B
Lactation: Unknown whether drug is excreted in milk
Interactions
Concomitant admin w/ antacids or Fe supplements reduce the rate and extent of absorption. Admin w/ Fe supplements may cause reddish stools. Decreased renal elimination w/ probenecid.
Side Effects
Side effects of Cefdinir :
>10%
Diarrhea (8-15%)
1-10%
Vaginal moniliasis (<4%), Nausea (3%), Rash (3%), Headache (2%), Increased urine leukocytes (2%), Increased urine protein (1-2%), Decreased lymphocytes (1%), Glycosuria (1%), Increased alkaline phosphatase (1%), Increased eosinophils (1%), Increased platelets (1%)
Potentially Fatal: Anaphylaxis; renal and hepatic failure.
Mode of Action
Cefdinir binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Adinir 300mg Capsule generic name is Cefdinir. Adinir 300mg Capsule is manufactured by Acme Laboratories Ltd.Adinir is availble in all over Bangladesh.
Mes BD drug index information on Adinir Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.