Accolate Tablet
Zafirlukast
20mg
Astrazeneca Pharmaceutical company
| Pack size | 30's pack |
|---|---|
| Unite Price | 26.26 BDT |
Indications
Accolate Tablet is used for:
Chronic asthma
Adult Dose
Oral
Chronic asthma
Adult: 20 mg bid.
Hepatic impairment: Contraindicated.
Child Dose
Oral
Chronic asthma
Child: 5-11 yr: 10 mg bid.
>12 yr: 20 mg bid.
Renal Dose
Renal Impairment
Dose adjustment not necessary
Administration
Should be taken on an empty stomach. Take at least 1 hr before or 2 hr after meals.
Contra Indications
Hypersensitivity, hepatic impairment, cirrhosis, acute asthmatic attacks. Lactation.
Precautions
Not indicated for use in the reversal of bronchospasm in acute asthma attacks. Avoid abrupt substitution to oral or inhaled corticosteroids. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor for improvements in air flow; monitor closely for sign/symptoms of hepatic injury; periodic monitoring of LFTs.
Lactation: Excreted in breast milk; not recommended
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Excreted in breast milk; not recommended
Interactions
May enhance anticoagulant activity of warfarin resulting to increased prothrombin time. Decreased plasma levels w/ theophylline, terfenadine and erythromycin. Increased plasma levels w/ fluconazole and high dose aspirin.
Side Effects
Side effects of Zafirlukast :
>10%
headache (12.9% in age >12 yr)
1-10%
Abdominal pain (1.8%), Infection (3.5%), Nausea (3.1%), Diarrhea (2.8%), Generalized pain (1.8%), Vomiting (1.5%), Dyspepsia/gastritits (1.3%), Increased ALT (1.5%), Infection (4%), Back pain (2%), Weakness (2%), Myalgia (2%)
Frequency Not Defined
Eosinophilia
Eosinophilic pneumonia
Vasculitis
Malaise
Bleeding
Bruising
Potentially Fatal: Severe hepatotoxicity.
Mode of Action
Zafirlukast selectively antagonises the leukotriene D4 receptor. It inhibits bronchoconstriction caused by various inhaled antigens or irritants. It is not used in acute asthma attacks.
Note
Accolate 20mg Tablet generic name is Zafirlukast. Accolate 20mg Tablet is manufactured by Astrazeneca Pharmaceutical companyAccolate is availble in all over Bangladesh.
Mes BD drug index information on Accolate Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.