Indications
Acaril Tablet is used for:
Type 2 DM
Adult Dose
Dosage Adult: PO Initial: 25 mg/day q8hr. May adjust gradually. Maintenance: 50-100 mg 3 times/day.
Max: <60 kg: 50 mg 3 times/day.
>60 kg: 100 mg 3 times/day.
Hepatic Impairment Severe: Contraindicated.
Child Dose
Renal Dose
Renal Impairment
CrCl Dosage
<25 Contraindicated.
Administration
Should be taken with food. Take w/ 1st bite of each main meal.
Contra Indications
Patients <18 yr; diabetic ketoacidosis or cirrhosis; malabsorption; inflammatory bowel disease; with or pre-disposed to intestinal obstruction; intestinal diseases that affect digestion or absorption; conditions that worsen as a result of increased gas formation e.g. hernias; colonic ulcers; hepatic impairment; CrClr< 25 ml/min/1.73m2. Pregnancy, lactation.
Precautions
Monitor LFT every 3 mth for 1st yr and periodically thereafter especially for doses >50 mg tid. Reduce dose or withdraw therapy if transaminases elevations persist. If hypoglycaemia occurs, give glucose orally as a 1st aid measure. Adhere strictly to the prescribed diabetic diet to avoid intensification of GI symptoms.
Lactation: not known if crosses into breast milk, avoid using in nursing women.
Pregnancy-Lactation
Pregnancy Category: B
Lactation: not known if crosses into breast milk, avoid using in nursing women
Interactions
May enhance effects of other antidiabetics including insulin. Diminished effects w/ GI adsorbents (e.g. charcoal) and digestive enzyme preparations containing carbohydrate splitting enzymes (e.g. amylase, pancreatin). Neomycin and colestyramine may enhance effects of acarbose. May inhibit absorption of digoxin.
Side Effects
Side effects of Acarbose :
>10%
abdominal pain (19%), diarrhea (31%), elevated serum transaminases, flatulence (74%)
Potentially Fatal: Hepatotoxicity.
Mode of Action
Acarbose competitively and reversibly inhibits pancreatic alpha-amylase and intestinal brush border alpha-glucosidases, resulting in retardation of glucose absorption from hydrolysed complex carbohydrates and reduction of blood-glucose concentrations.
Note
Acaril 50mg Tablet generic name is Acarbose. Acaril 50mg Tablet is manufactured by White Horse PharmaAcaril is availble in all over Bangladesh.
Mes BD drug index information on Acaril Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.