Abixa 10 Tablet

Memantine Hydrochloride
10mg
ACI Limited
Pack size 20's pack
Unite Price 8.00 BDT

Indications

Abixa 10 Tablet is used for: Alzheimer's dementia.

Adult Dose

Oral Moderate to severe dementia in Alzheimer's disease Adult: As hydrochloride: Initially, 5 mg daily in the morning for the 1st wk; increase dose wkly in steps of 5 mg. Max: 20 mg daily. Wait for at least 1 wk between dose changes. Doses >10 mg/day should be given in 2 divided doses. Suggested titration: 5 mg daily for >1 wk; 5 mg bid for >1 wk; 15 mg daily given in 5- and 10-mg separated doses for >1 wk; then 10 mg bid. Hepatic impairment Mild or moderate (Child Pugh A/B): No dosage adjustment required Severe (Child Pugh C): Caution

Child Dose

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation 5-29 Max: 10 mg daily. 30-49 10 mg daily (after initial dose of 5 mg daily), if well tolerated for at least 7 days, may increase to 20 mg daily.

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity to memantine or components of the formulation. Severe renal impairment.

Precautions

Renal impairment; epilepsy. Pregnancy and lactation. Closely monitor patients with recent MI, uncompensated CHF, uncontrolled hypertension. Predisposition to convulsions; conditions that increase urinary pH. Lactation: Unknown whether drug is excreted into breast milk; use with caution

Pregnancy-Lactation

Pregnancy There are no adequate data on developmental risk associated with use; adverse developmental effects (decreased body weight, and skeletal ossification) observed in offspring of rats during pregnancy at doses associated with minimal maternal toxicity; doses are higher than used in humans at maximum recommended daily dose Animal data Oral administration to rats during period of organogenesis resulted in decreased skeletal ossification in fetuses at highest dose tested; the higher no-effect dose (6 mg/kg/day) was approximately 3 times MRHD on a mg/m² basis Oral administration of memantine to rabbits during period of organogenesis resulted in no adverse developmental effects; highest dose tested was approximately 30 times the MRHD on a mg/m² basis Oral administration to rats from late gestation throughout lactation to weaning, resulted in decreased pup weights at highest dose tested; the higher no-effect dose (6 mg/kg/day) is approximately 3 times the MRHD on a mg/ m² basis Lactation There are no data on presence of drug in human milk, effects on breastfed infant, or on milk production Developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from drug or from underlying maternal condition

Interactions

May increase effects of antimuscarinics and dopaminergics. May reduce effects of antipsychotics and barbiturates. May alter effects of dantrolene, baclofen. Reduced clearance with carbonic anhydrase inhibitors and sodium bicarbonate. Potentially Fatal: Increased risk of adverse effects with amantadine, dextromethorphan or ketamine.

Side Effects

Side effects of Memantine Hydrochloride : 1-10% Dizziness (7%), Confusion (6%), Headache (6%), Constipation (5%), Cough (4%), Hypertension (4%), Backache (3%), Pain (3%), Somnolence (3%), Syncope (3%), Vomiting (3%), Dyspnea (2%), Fatigue (2%) <1% Acute renal failure, Cerebral infarction, Cerebrovascular accident, Deep venous thrombosis, Hepatitis, liver failure, Intracranial hemorrhage, Neuroleptic malignant syndrome, Seizure (including grand mal), Stevens-Johnson syndrome, Transient ischemic attack

Mode of Action

Memantine, a derivative of amantadine, is a noncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist. It affects transmission of glutamate, the primary excitatory neurotransmitter in the CNS. Glutamate may contribute to the pathogenesis of Alzheimer's disease by overstimulating various glutamate receptors resulting in excitotoxicity and neuronal cell death.

Note

Abixa 10 10mg Tablet generic name is Memantine Hydrochloride. Abixa 10 10mg Tablet is manufactured by ACI LimitedAbixa 10 is availble in all over Bangladesh. Mes BD drug index information on Abixa 10 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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